caa a22 4500 465735371 CHVBK 20180323111753.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02427830 doi (NATIONALLICENCE)springer-10.1007/BF02427830 The VM model of glioma: Preparation of multicellular tumour spheroids (MTS) and their response to chemotherapy [Elektronische Daten] [R. Bradford, J. Darling, N. Sier, D. Thomas] Summary: A cell line, 497-P(1), derived from the VM spontaneous murine astrocytoma has been used to develop anin vitro therapeutic model of human glioma. In this study we describe the preparation of MTS from this cell line. The in vitro chemosensitivity of 497-P(1) MTS has been examined and compared to the sensitivity of the monolayer culture. BCNU and CCNU both produced growth delay in MTS at doses below the ID50 of the monolayer culture. MTS, however, were considerably more resistant to vincristine and procarbazine when compared to the monolayer culture. Kluwer Academic Publishers, 1990 multicellular tumour spheroids nationallicence antineoplastic agents nationallicence brain neoplasms nationallicence neoplasms nationallicence experimental nationallicence Bradford R. Neuro-oncology Section, Gough-Cooper Department of Neurological Surgery, Institute of Neurology, Queen Square, WCIN 3BG, London, UK aut Darling J. Neuro-oncology Section, Gough-Cooper Department of Neurological Surgery, Institute of Neurology, Queen Square, WCIN 3BG, London, UK aut Sier N. Neuro-oncology Section, Gough-Cooper Department of Neurological Surgery, Institute of Neurology, Queen Square, WCIN 3BG, London, UK aut Thomas D. Neuro-oncology Section, Gough-Cooper Department of Neurological Surgery, Institute of Neurology, Queen Square, WCIN 3BG, London, UK aut Journal of Neuro-Oncology Kluwer Academic Publishers 9/2(1990-10-01), 105-114 0167-594X 9:2<105 1990 9 11060 https://doi.org/10.1007/BF02427830 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02427830 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bradford R. Neuro-oncology Section, Gough-Cooper Department of Neurological Surgery, Institute of Neurology, Queen Square, WCIN 3BG, London, UK aut NATIONALLICENCE 700 1- Darling J. Neuro-oncology Section, Gough-Cooper Department of Neurological Surgery, Institute of Neurology, Queen Square, WCIN 3BG, London, UK aut NATIONALLICENCE 700 1- Sier N. Neuro-oncology Section, Gough-Cooper Department of Neurological Surgery, Institute of Neurology, Queen Square, WCIN 3BG, London, UK aut NATIONALLICENCE 700 1- Thomas D. Neuro-oncology Section, Gough-Cooper Department of Neurological Surgery, Institute of Neurology, Queen Square, WCIN 3BG, London, UK aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 9/2(1990-10-01), 105-114 0167-594X 9:2<105 1990 9 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer