caa a22 4500 465735401 CHVBK 20180323111753.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02427832 doi (NATIONALLICENCE)springer-10.1007/BF02427832 In vitro Prostaglandin E2 production by glioblastoma cells and its effect on interleukin-2 activation of oncolytic lymphocytes [Elektronische Daten] [Yutaka Sawamura, Annie-Claire Diserens, Nicolas de Tribolet] Summary: Glioblastoma cells constitutively produce various amounts of PGEZ (prostaglandin E2)in vitro. The amounts of PGE2 found in the conditioned medium of the glioblastoma cultures (less than 5 ng/ml) were not enough to inhibit the IL-2 (interleukin-2) activation of peripheral blood lymphocytes. However the amount of PGE2 produced by approximately 1 x 107 of the glioblastoma cells can be assumed to suppress the generation of IL-2-induced killing activity against glioblastoma cells. Kluwer Academic Publishers, 1990 brain tumor nationallicence glioblastoma nationallicence immunotherapy nationallicence interleukin 2 nationallicence lymphokine activated killer cell nationallicence prostaglandin E2 nationallicence Sawamura Yutaka Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland aut Diserens Annie-Claire Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland aut de Tribolet Nicolas Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland aut Journal of Neuro-Oncology Kluwer Academic Publishers 9/2(1990-10-01), 125-130 0167-594X 9:2<125 1990 9 11060 https://doi.org/10.1007/BF02427832 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02427832 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sawamura Yutaka Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland aut NATIONALLICENCE 700 1- Diserens Annie-Claire Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland aut NATIONALLICENCE 700 1- de Tribolet Nicolas Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 9/2(1990-10-01), 125-130 0167-594X 9:2<125 1990 9 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer