caa a22 4500 46573541X CHVBK 20180323111753.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02427834 doi (NATIONALLICENCE)springer-10.1007/BF02427834 Familial clustering of malignant astrocytomas [Elektronische Daten] [Dominique Lossignol, Stuart Grossman, Vivian Sheidler, Constance Griffin, Steven Piantadosi] Three of 32 consecutive patients with astrocytomas enrolled in an experimental chemotherapy protocol had at least one first degree relative with an astrocytoma. These patients did not have family members with an excess of malignancies, known exposure to a specific environmental factor, or a recognized neurocutaneous syndrome. In all three families, the illnesses temporally overlapped and the age of the patients affected in the second generation was less than those in the first generation. An estimation of the probability of developing astrocytomas in families with one affected individual strongly suggests a familial effect. Our observations, coupled with other cases reported in the literature, suggest that familial astrocytomas occur more frequently than is currently recognized. Identification and careful study of such families may provide important clues to the etiology of these malignancies. Kluwer Academic Publishers, 1990 brain tumors nationallicence glioblastoma nationallicence multiforme nationallicence astrocytoma nationallicence etiology nationallicence familial nationallicence genetic nationallicence environmental nationallicence infectious nationallicence Lossignol Dominique The Johns Hopkins Oncology Center, 600 N. Wolfe Street, Room 132, 21205, Baltimore, MD, USA aut Grossman Stuart The Johns Hopkins Oncology Center, 600 N. Wolfe Street, Room 132, 21205, Baltimore, MD, USA aut Sheidler Vivian The Johns Hopkins Oncology Center, 600 N. Wolfe Street, Room 132, 21205, Baltimore, MD, USA aut Griffin Constance The Johns Hopkins Oncology Center, 600 N. Wolfe Street, Room 132, 21205, Baltimore, MD, USA aut Piantadosi Steven The Johns Hopkins Oncology Center, 600 N. Wolfe Street, Room 132, 21205, Baltimore, MD, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 9/2(1990-10-01), 139-145 0167-594X 9:2<139 1990 9 11060 https://doi.org/10.1007/BF02427834 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02427834 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lossignol Dominique The Johns Hopkins Oncology Center, 600 N. Wolfe Street, Room 132, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Grossman Stuart The Johns Hopkins Oncology Center, 600 N. Wolfe Street, Room 132, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Sheidler Vivian The Johns Hopkins Oncology Center, 600 N. Wolfe Street, Room 132, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Griffin Constance The Johns Hopkins Oncology Center, 600 N. Wolfe Street, Room 132, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Piantadosi Steven The Johns Hopkins Oncology Center, 600 N. Wolfe Street, Room 132, 21205, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 9/2(1990-10-01), 139-145 0167-594X 9:2<139 1990 9 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer