caa a22 4500 465735436 CHVBK 20180323111753.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00182090 doi (NATIONALLICENCE)springer-10.1007/BF00182090 Vascular response to irradiation in malignant gliomas [Elektronische Daten] [Davide Schiffer, Adriano Chiò, Maria Giordana, Alessandro Mauro, Antonio Migheli, Riccardo Soffietti, Maria Vigliani] Summary: The vascular response to irradiation was studied in peritumoral cortex and tumor areas in 9 autopsied cases of glioblastoma multiforme and in 10 biopsies of reoperated cases. The study was carried out by histological, immunohistochemical and electron microscope procedures. Hyaline thickening of the vessel walls with deformation and impoverishment of endothelial nuclei are the most striking features. Formation of large PAS-positive areas from the confluence of thickened vessel walls and development of a fibroblastic proliferation follow. Fibroblastic areas may entrap tumor glial cells. In PAS-positive areas a special population resembles myofibroblasts of tissue scars. Electron microscope reveals the production of collagen fibrils in and outside vessel walls. The presence of collagen III and IV is in line with the present interpretation of the mesodermic component. Kluwer Academic Publishers, 1990 vessels nationallicence irradiation nationallicence glioblastoma nationallicence Schiffer Davide II Department of Neurology, University of Turin, Turin, Italy aut Chiò Adriano II Department of Neurology, University of Turin, Turin, Italy aut Giordana Maria II Department of Neurology, University of Turin, Turin, Italy aut Mauro Alessandro II Department of Neurology, University of Turin, Turin, Italy aut Migheli Antonio II Department of Neurology, University of Turin, Turin, Italy aut Soffietti Riccardo II Department of Neurology, University of Turin, Turin, Italy aut Vigliani Maria II Department of Neurology, University of Turin, Turin, Italy aut Journal of Neuro-Oncology Kluwer Academic Publishers 8/1(1990-02-01), 73-84 0167-594X 8:1<73 1990 8 11060 https://doi.org/10.1007/BF00182090 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00182090 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schiffer Davide II Department of Neurology, University of Turin, Turin, Italy aut NATIONALLICENCE 700 1- Chiò Adriano II Department of Neurology, University of Turin, Turin, Italy aut NATIONALLICENCE 700 1- Giordana Maria II Department of Neurology, University of Turin, Turin, Italy aut NATIONALLICENCE 700 1- Mauro Alessandro II Department of Neurology, University of Turin, Turin, Italy aut NATIONALLICENCE 700 1- Migheli Antonio II Department of Neurology, University of Turin, Turin, Italy aut NATIONALLICENCE 700 1- Soffietti Riccardo II Department of Neurology, University of Turin, Turin, Italy aut NATIONALLICENCE 700 1- Vigliani Maria II Department of Neurology, University of Turin, Turin, Italy aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 8/1(1990-02-01), 73-84 0167-594X 8:1<73 1990 8 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer