caa a22 4500 465735487 CHVBK 20180323111753.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00182091 doi (NATIONALLICENCE)springer-10.1007/BF00182091 Combined treatment of anaplastic astrocytoma (grade 3-4) with diacetyl-dianhydro-galactitol (DADAG) [Elektronische Daten] [Dénes Áfra, Sändor Kerpel-Fronius, István Szinai, Béla Kocsis, Sändor Eckhardt] Summary: Autoradiographic studies of labeled diacetyldianhydro-galactitol (DADAG) with tumor bearing animals revealed that the CNS accumulates high amounts of DADAG-derived radioactivity and the elimination from the brain seems to be relatively slow. This observation and the activity of DADAG against murine ependymoblastoma classified the drug as a promising agent for the treatment of malignant brain tumors. In a series of 30 evaluable consecutive patients who were operated on for anaplastic astrocytomas, DADAG has been applied during and subsequent to postoperative radiotherapy. No severe toxicity occurred. Survivals were compared with a group of patients who got irradiation alone. Statistical analysis did not show significantly better survivals in the DADAG treated group: median value was 46.5 weeks, p = 0.232. Kluwer Academic Publishers, 1990 malignant glioma nationallicence radiotherapy nationallicence DADAG nationallicence Áfra Dénes National Institute of Neurosurgery, H-1145, Budapest, Amerikai fit 57, Hungary aut Kerpel-Fronius Sändor National Institute of Neurosurgery, H-1145, Budapest, Amerikai fit 57, Hungary aut Szinai István National Institute of Neurosurgery, H-1145, Budapest, Amerikai fit 57, Hungary aut Kocsis Béla National Institute of Neurosurgery, H-1145, Budapest, Amerikai fit 57, Hungary aut Eckhardt Sändor National Institute of Neurosurgery, H-1145, Budapest, Amerikai fit 57, Hungary aut Journal of Neuro-Oncology Kluwer Academic Publishers 8/1(1990-02-01), 85-91 0167-594X 8:1<85 1990 8 11060 https://doi.org/10.1007/BF00182091 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00182091 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Áfra Dénes National Institute of Neurosurgery, H-1145, Budapest, Amerikai fit 57, Hungary aut NATIONALLICENCE 700 1- Kerpel-Fronius Sändor National Institute of Neurosurgery, H-1145, Budapest, Amerikai fit 57, Hungary aut NATIONALLICENCE 700 1- Szinai István National Institute of Neurosurgery, H-1145, Budapest, Amerikai fit 57, Hungary aut NATIONALLICENCE 700 1- Kocsis Béla National Institute of Neurosurgery, H-1145, Budapest, Amerikai fit 57, Hungary aut NATIONALLICENCE 700 1- Eckhardt Sändor National Institute of Neurosurgery, H-1145, Budapest, Amerikai fit 57, Hungary aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 8/1(1990-02-01), 85-91 0167-594X 8:1<85 1990 8 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer