caa a22 4500 465735533 CHVBK 20180323111753.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00182086 doi (NATIONALLICENCE)springer-10.1007/BF00182086 Failure of betamethasone to alter the radiation response of two cultured human glioma cell-lines [Elektronische Daten] [Gudmundur Benediktsson, Erik Blomquist, Jörgen Carlsson] Summary: Glucocorticoids, such as betamethasone, are often used to prevent possible acute reactions during radiation therapy of intracranial tumors (for example gliomas). The effect of the glucocorticoids is probably due to vascular changes decreasing the development of edemas. The radiosensitivity of two studied cell-lines of human malignant glioma origin did not significantly change when they were continuously exposed to betamethasone in the concentration range of 1-25 µg/ml. The radiosensitivity was measured with the extrapolation method, which gave an estimate of cell survival, and through direct measurements of growth delays from growth curves. The results obtained are in conformity with previously published results where clonogenic survival tests showed that the isomer dexamethasone did not change the radiosensitivity of these cells. Thus, no direct effects on the radiosensitivity of glioma cells are expected from glucocorticoid treatment and it is therefore unlikely that the poor results obtained from radiation therapy of malignant gliomas are due to an increased radioresistance brought on by the glucocorticoid treatment. Kluwer Academic Publishers, 1990 betamethasone nationallicence cell culture nationallicence glioma cells nationallicence glucocorticoids nationallicence growth curves nationallicence radiation effects nationallicence Benediktsson Gudmundur Department of Oncology, University Hospital, Reykjavik, Iceland aut Blomquist Erik Department of Oncology, University Hospital (Akademiska sjukhuset), Uppsala University, S-75185, Uppsala, Sweden aut Carlsson Jörgen Department of physical biology, Institute of Radiation Sciences, Uppsala University, Box 535, S-75121, Uppsala, Sweden aut Journal of Neuro-Oncology Kluwer Academic Publishers 8/1(1990-02-01), 47-53 0167-594X 8:1<47 1990 8 11060 https://doi.org/10.1007/BF00182086 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00182086 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Benediktsson Gudmundur Department of Oncology, University Hospital, Reykjavik, Iceland aut NATIONALLICENCE 700 1- Blomquist Erik Department of Oncology, University Hospital (Akademiska sjukhuset), Uppsala University, S-75185, Uppsala, Sweden aut NATIONALLICENCE 700 1- Carlsson Jörgen Department of physical biology, Institute of Radiation Sciences, Uppsala University, Box 535, S-75121, Uppsala, Sweden aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 8/1(1990-02-01), 47-53 0167-594X 8:1<47 1990 8 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer