caa a22 4500 465735568 CHVBK 20180323111754.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00182088 doi (NATIONALLICENCE)springer-10.1007/BF00182088 Lack of efficacy of megestrol acetate in the treatment of unresectable meningioma [Elektronische Daten] [Steven Grunberg, Martin Weiss] The detection of hormone receptors on meningiomas raises the possibility of hormonal manipulation as a form of therapy. Since progesterone receptors are found on meningiomas more frequently and in greater amounts than estrogen receptors, manipulation of progesterone levels would be most promising. A trial of the oral progesterone agonist megestrol acetate for the treatment of unresectable meningioma was therefore performed. Megestrol acetate was administered at a dose of 40 mg four times daily which could be escalated to 80 mg four times daily. Nine patients (six meningothelial, two fibrous, and one anaplastic meningiomas) were treated for 1 to 12 months. No tumor responses were seen. However three patients required discontinuation of therapy due to deteriorating vision within 2 1/2 months. The major systemic toxicity of megestrol acetate was weight gain with a median weight gain of 14 kg for patients treated for at least 6 months. Due to the lack of efficacy and the significant toxicity noted, megestrol acetate is not recommended for the treatment of meningioma. However clinical trials of progesterone antagonists would still be of interest. Kluwer Academic Publishers, 1990 meningioma nationallicence progesterone nationallicence megestrol acetate nationallicence Grunberg Steven Division of Medical Oncology, University of Southern California Comprehensive Cancer Center, 2025 Zonal Avenue Rm., GH 10-436, 90033, Los Angeles, California, USA aut Weiss Martin Department of Neurosurgery, University of Southern California School of Medicine, Los Angeles, California, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 8/1(1990-02-01), 61-65 0167-594X 8:1<61 1990 8 11060 https://doi.org/10.1007/BF00182088 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00182088 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grunberg Steven Division of Medical Oncology, University of Southern California Comprehensive Cancer Center, 2025 Zonal Avenue Rm., GH 10-436, 90033, Los Angeles, California, USA aut NATIONALLICENCE 700 1- Weiss Martin Department of Neurosurgery, University of Southern California School of Medicine, Los Angeles, California, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 8/1(1990-02-01), 61-65 0167-594X 8:1<61 1990 8 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer