caa a22 4500 465735576 CHVBK 20180323111754.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00182085 doi (NATIONALLICENCE)springer-10.1007/BF00182085 Sensitivity of human malignant intracranial tumors against MCNU in vitro in comparison to ACNU and BCNU [Elektronische Daten] [J.C. Tonn, R. Schönmayr, H.-P. Kraemer] Summary: An in vitro chemosensitivity test was carried out in 50 specimen of human malignant intracranial tumors. Aim of the study was to evaluate the proportion of sensitivity against MCNU (Ranomustine) in comparison to ACNU and BCNU. 47 tests were evaluable. Mean viability of the specimen was 83.3 ± 18.7%, mean plating efficiency was 0.068 ± 0.051%. 9/47 settings revealed sensitivity against MCNU in vitro (ACNU: 10/47; BCNU: 16/46). There was no advantage of MCNU concerning age or sex of the patients. Brain metastases seemed to be slightly more frequent sensitive against MCNU than primary brain tumors. Cross resistance between ACNU, BCNU and MCNU was rather high. The results of this in vitro series do not encourage a clinical trial of MCNU as an alternative to the commonly used nitrosoureas. Kluwer Academic Publishers, 1990 MCNU nationallicence ACNU nationallicence BCNU nationallicence brain tumors nationallicence chemosensitivity test nationallicence colony forming assay nationallicence Tonn J.C. Neurosurgical Department (Prof. Dr. K. Roosen) JLU Giessen, Klinikstr. 29, D-6300, Giessen, FRG aut Schönmayr R. Neurosurgical Department (Prof. Dr. K. Roosen) JLU Giessen, Klinikstr. 29, D-6300, Giessen, FRG aut Kraemer H.-P Neurosurgical Department (Prof. Dr. K. Roosen) JLU Giessen, Klinikstr. 29, D-6300, Giessen, FRG aut Journal of Neuro-Oncology Kluwer Academic Publishers 8/1(1990-02-01), 41-45 0167-594X 8:1<41 1990 8 11060 https://doi.org/10.1007/BF00182085 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00182085 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tonn J.C. Neurosurgical Department (Prof. Dr. K. Roosen) JLU Giessen, Klinikstr. 29, D-6300, Giessen, FRG aut NATIONALLICENCE 700 1- Schönmayr R. Neurosurgical Department (Prof. Dr. K. Roosen) JLU Giessen, Klinikstr. 29, D-6300, Giessen, FRG aut NATIONALLICENCE 700 1- Kraemer H.-P Neurosurgical Department (Prof. Dr. K. Roosen) JLU Giessen, Klinikstr. 29, D-6300, Giessen, FRG aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 8/1(1990-02-01), 41-45 0167-594X 8:1<41 1990 8 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer