caa a22 4500 465735622 CHVBK 20180323111754.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00177354 doi (NATIONALLICENCE)springer-10.1007/BF00177354 A new rat brain tumor model: Glioma disseminated via the cerebral spinal fluid pathways [Elektronische Daten] [Arleta Rewers, Edward Redgate, Melvin Deutsch, Edwin Fisher, Sallie Boggs] Summary: A rat brain tumor model has been developed with the clinical and pathological features of dissemination via the cerebral spinal fluid (CSF) pathways. A precise number of 9L gliosarcoma cells (5 × 102 to 5 × 105) is stereotactically injected into the CSF of the lateral ventricle. The interval until the onset of neurological symptoms and then death is reproducible and dependent upon the number of cells injected. The median survival of three groups of rats receiving 5 × 105 cells in three different experiments was 17, 18 and 19 days respectively. For three groups receiving 5 × 104 cells, the median survival was 23, 24 and 25.5 days respectively and for two groups receiving 5 × 103 cells the median survival was 28 and 30 days respectively. The animals developed multiple tumor implants along the CSF pathways usually resulting in hydrocephalus. This tumor model was developed to simulate dissemination via CSF pathways as seen with medulloblastoma and other primitive neuroectodermal tumors of the central nervous system. It will be used to evaluate the therapeutic efficacy of intra-ventricularly administered anti-neoplastic drugs against small implants and malignant cells in the CSF pathways. Kluwer Academic Publishers, 1990 9L gliosarcoma nationallicence tumor model nationallicence brain tumor nationallicence stereotactic implantation nationallicence Rewers Arleta Department of Radiation Oncology, University of Pittsburgh, School of Medicine, 15213, Pittsburgh, PA, USA aut Redgate Edward Department of Physiology, University of Pittsburgh, School of Medicine, 15213, Pittsburgh, PA, USA aut Deutsch Melvin Department of Radiation Oncology, University of Pittsburgh, School of Medicine, 15213, Pittsburgh, PA, USA aut Fisher Edwin Department of Pathology, Shadyside Hospital, 15232, Pittsburgh, PA, USA aut Boggs Sallie Department of Radiation Oncology, University of Pittsburgh, School of Medicine, 15213, Pittsburgh, PA, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 8/3(1990-06-01), 213-219 0167-594X 8:3<213 1990 8 11060 https://doi.org/10.1007/BF00177354 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177354 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rewers Arleta Department of Radiation Oncology, University of Pittsburgh, School of Medicine, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Redgate Edward Department of Physiology, University of Pittsburgh, School of Medicine, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Deutsch Melvin Department of Radiation Oncology, University of Pittsburgh, School of Medicine, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Fisher Edwin Department of Pathology, Shadyside Hospital, 15232, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Boggs Sallie Department of Radiation Oncology, University of Pittsburgh, School of Medicine, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 8/3(1990-06-01), 213-219 0167-594X 8:3<213 1990 8 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer