caa a22 4500 465735649 CHVBK 20180323111754.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00177358 doi (NATIONALLICENCE)springer-10.1007/BF00177358 Treatment of malignant recurrent glioma by infra-arterial, infra-ophtalmic infusion of HECNU 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl) urea [Elektronische Daten] A phase II study [M. Poisson, J. Chiras, F. Fauchon, C. Debussche, J.Y. Delattre] Summary: 53 patients suffering from malignant recurrent glioma were treated with iterative arterial infusions of HECNU. The intra-carotid injections were performed below the ophtalmic artery. The response rate was 49% and the median survival was 8,5 months. The results differ substantially according to the histological subtype. The response rate was 33% for glioblastomas, 50% for anaplastic astrocytomas and 92% for malignant recurrences of low grade astrocytomas. The median survival was 4.5 months for glioblastomas and 18 months for anaplastic astrocytomas and malignant recurrences of low grade astrocytomas. Serious complications were a monocular blindness in 3 cases and a leucoencephalopathy in 6 cases. Kluwer Academic Publishers, 1990 malignant recurrent gliomas nationallicence anaplastic astrocytomas nationallicence glioblastomas nationallicence intra-arterial chemotherapy nationallicence nitrosourea nationallicence monocular blindness nationallicence leucoencephalopathy nationallicence Poisson M. Department of Neurology, La Salpêtrière, Paris, France aut Chiras J. Department of Neuroradiology, La Salpêtrière, Paris, France aut Fauchon F. Department of Radiotherapy, La Salpêtrière, Paris, France aut Debussche C. Department of Neuroradiology, La Salpêtrière, Paris, France aut Delattre J.Y. Department of Neurology, La Salpêtrière, Paris, France aut Journal of Neuro-Oncology Kluwer Academic Publishers 8/3(1990-06-01), 255-262 0167-594X 8:3<255 1990 8 11060 https://doi.org/10.1007/BF00177358 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177358 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Poisson M. Department of Neurology, La Salpêtrière, Paris, France aut NATIONALLICENCE 700 1- Chiras J. Department of Neuroradiology, La Salpêtrière, Paris, France aut NATIONALLICENCE 700 1- Fauchon F. Department of Radiotherapy, La Salpêtrière, Paris, France aut NATIONALLICENCE 700 1- Debussche C. Department of Neuroradiology, La Salpêtrière, Paris, France aut NATIONALLICENCE 700 1- Delattre J.Y. Department of Neurology, La Salpêtrière, Paris, France aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 8/3(1990-06-01), 255-262 0167-594X 8:3<255 1990 8 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer