caa a22 4500 465735657 CHVBK 20180323111754.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00177353 doi (NATIONALLICENCE)springer-10.1007/BF00177353 Modification of tumor blood flow and enhancement of therapeutic effect of ACNU on experimental rat gliomas with angiotensin II [Elektronische Daten] [Kouichi Tokuda, Hiroshi Abel, Toshimitsu Aida, Shinji Sugimoto, Sadao Kaneko] Blood flow was measured in transplanted rat gliomas before and during a constant intravenous infusion of angiotensin II using hydrogen clearance methods. The brain tumor models were produced in syngeneic Wister-King-Aptekman male rats with stereotaxic inoculation of ethylnitrosourea-induced glioma cells (KEG-1). Induced hypertension up to 150 mmHg (mean arterial pressure) with the infusion of angiotensin II resulted in a significant increase of blood flow to tumor center compared to the normotensive state (p < 0.001). Blood flow measured simultaneously in brain tissue of tumor-free contralateral hemisphere did not change. The therapeutic effect of administration of the simultaneous 1-(4-Amino-2-methyl-5-pyrimidinyl)methyl3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) and angiotensin II was evaluated in four experimental groups with the tumor-bearing rats. Twelve days after tumor implantation, the rats were administered angiotensin II to increase the mean arterial blood pressure to 150 mmHg, followed by intravenous injection of ACNU injection. The increased blood pressure was steadily maintained for 20 minutes. The ACNU/induced hypertension group showed a median survival time of 27.0 days, which was significant longer (p < 0.02) than that of an ACNU treatment group (22.0 days), a hypertension treatment group (19.0 days), or a no treatment group (18.5 days). The enhanced therapeutic effect can be attributed to improving chemotherapeutic drug delivery due to increased blood flow in the tumor. Kluwer Academic Publishers, 1990 experimental glioma nationallicence ACNU nationallicence angiotensin II nationallicence experimental chemotherapy nationallicence tumor blood flow nationallicence Tokuda Kouichi Department of Neurosurgery, University of Hokkaido School of Medicine, North 14, West 5, Kita-ku, 060, Sapporo, Hokkaido, Japan aut Abel Hiroshi Department of Neurosurgery, University of Hokkaido School of Medicine, North 14, West 5, Kita-ku, 060, Sapporo, Hokkaido, Japan aut Aida Toshimitsu Department of Neurosurgery, University of Hokkaido School of Medicine, North 14, West 5, Kita-ku, 060, Sapporo, Hokkaido, Japan aut Sugimoto Shinji Department of Neurosurgery, University of Hokkaido School of Medicine, North 14, West 5, Kita-ku, 060, Sapporo, Hokkaido, Japan aut Kaneko Sadao Department of Neurosurgery, Iwamizawa City Hospital, Iwamizawa, Japan aut Journal of Neuro-Oncology Kluwer Academic Publishers 8/3(1990-06-01), 205-212 0167-594X 8:3<205 1990 8 11060 https://doi.org/10.1007/BF00177353 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177353 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tokuda Kouichi Department of Neurosurgery, University of Hokkaido School of Medicine, North 14, West 5, Kita-ku, 060, Sapporo, Hokkaido, Japan aut NATIONALLICENCE 700 1- Abel Hiroshi Department of Neurosurgery, University of Hokkaido School of Medicine, North 14, West 5, Kita-ku, 060, Sapporo, Hokkaido, Japan aut NATIONALLICENCE 700 1- Aida Toshimitsu Department of Neurosurgery, University of Hokkaido School of Medicine, North 14, West 5, Kita-ku, 060, Sapporo, Hokkaido, Japan aut NATIONALLICENCE 700 1- Sugimoto Shinji Department of Neurosurgery, University of Hokkaido School of Medicine, North 14, West 5, Kita-ku, 060, Sapporo, Hokkaido, Japan aut NATIONALLICENCE 700 1- Kaneko Sadao Department of Neurosurgery, Iwamizawa City Hospital, Iwamizawa, Japan aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 8/3(1990-06-01), 205-212 0167-594X 8:3<205 1990 8 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer