caa a22 4500 465735681 CHVBK 20180323111754.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00177360 doi (NATIONALLICENCE)springer-10.1007/BF00177360 Small cell carcinoma of the large intestine presenting as central nervous systems signs and symptoms. Two case reports with literature review [Elektronische Daten] [Atif Hussein, Lynn Feun, Kasi Sridhar, Christian Otrakji, Maria Garcia-Moore, Pasquale Benedetto] Extrapulmonary small cell carcinoma is rare. Small cell carcinoma of the colorectum has been reported in 73 patients. Patients with colorectal small cell carcinoma present with signs and symptoms related to the primary site. Usually patients present with advanced stage. Rarely do patients with colorectal small cell carcinoma present with signs and symptoms related to the central nervous system (CNS). We report two patients who presented with CNS signs. The two patients underwent craniotomy for definitive diagnosis and resection in one patient. In both cases, pathology was consistent with pure small cell carcinoma. Postoperatively, a search for a primary revealed the rectum and the hepatic flexure of the colon to be the sites. Patients were started on combination chemotherapy. One patient achieved a complete remission and the second is currently receiving chemotherapy with a partial response. This is the first report of colorectal small cell carcinoma presenting as CNS lesion(s). Kluwer Academic Publishers, 1990 small cell carcinoma nationallicence colon nationallicence rectum nationallicence chemotherapy nationallicence central nervous system nationallicence cerebellum nationallicence Hussein Atif Department of Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital and V.A. Hospital, 33136, Miami, FL, USA aut Feun Lynn Department of Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital and V.A. Hospital, 33136, Miami, FL, USA aut Sridhar Kasi Department of Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital and V.A. Hospital, 33136, Miami, FL, USA aut Otrakji Christian Department of Pathology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital and V.A. Hospital, 33136, Miami, FL, USA aut Garcia-Moore Maria Department of Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital and V.A. Hospital, 33136, Miami, FL, USA aut Benedetto Pasquale Department of Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital and V.A. Hospital, 33136, Miami, FL, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 8/3(1990-06-01), 269-274 0167-594X 8:3<269 1990 8 11060 https://doi.org/10.1007/BF00177360 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177360 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hussein Atif Department of Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital and V.A. Hospital, 33136, Miami, FL, USA aut NATIONALLICENCE 700 1- Feun Lynn Department of Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital and V.A. Hospital, 33136, Miami, FL, USA aut NATIONALLICENCE 700 1- Sridhar Kasi Department of Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital and V.A. Hospital, 33136, Miami, FL, USA aut NATIONALLICENCE 700 1- Otrakji Christian Department of Pathology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital and V.A. Hospital, 33136, Miami, FL, USA aut NATIONALLICENCE 700 1- Garcia-Moore Maria Department of Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital and V.A. Hospital, 33136, Miami, FL, USA aut NATIONALLICENCE 700 1- Benedetto Pasquale Department of Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital and V.A. Hospital, 33136, Miami, FL, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 8/3(1990-06-01), 269-274 0167-594X 8:3<269 1990 8 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer