caa a22 4500 465735754 CHVBK 20180323111754.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00177833 doi (NATIONALLICENCE)springer-10.1007/BF00177833 Bone metastases of medulloblastoma in childhood; correlation with flow cytometric DNA analysis [Elektronische Daten] [Tadanori Tomita, Lakshmi Das, Mary Radkowski] Thirty children with medulloblastoma who were treated between 1980 and 1986 are presented. Flow cytometric DNA analysis using formalin-fixed and paraffin-embedded tissues showed that 15 were DNA aneuploid,13 diploid and 2 tetraploid. After homogeneous treatment with a combination of radical resection and radiation therapy, patients with DNA aneuploid medulloblastoma showed significantly better outcome (p = 0.003). Among these 30 patients, 6 (20%) had bone metastases of medulloblastoma during a minimum of 2-year follow-up period. DNA ploidy of these patients was diploid in 5 and aneuploid in 1. Incidence of bone metastases appears to correlate with DNA ploidy (p = 0.046). At the time of discovery of bone metastases, 4 had no demonstrable recurrence in the central nervous system (CNS). Radionuclide bone scan was more sensitive in disclosing these lesions, while only one patient had positive results of bone marrow aspirates/ biopsy. Three patients were treated with chemotherapy, two had a combination of regional irradiation and chemotherapy and one refused treatment. All treated bone metastases in 5 patients responded clinically and radiographically, but only one patient is alive 66 months after therapy. Four patients died due to either CNS recurrence or septic complication of chemotherapy. Early detection of bone metastases by use of frequent bone scans is important. Patients with diploid medulloblastoma should be treated with adjuvant chemotherapy in order to prevent recurrences and metastases. Kluwer Academic Publishers, 1990 medulloblastoma nationallicence brain neoplasms nationallicence bone neoplasms nationallicence chemotherapy nationallicence DNA ploidy nationallicence flow cytometry nationallicence Tomita Tadanori Division of Pediatric Neurosurgery, Children's Memorial Hospital, 2300 N. Children's Plaza, 60614, Chicago, Il, USA aut Das Lakshmi Division of hematology/Oncology, Children's Memorial Hospital, Illinois, USA aut Radkowski Mary Department of Radiology, Children's Memorial Hospital, Illinois, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 8/2(1990-04-01), 113-120 0167-594X 8:2<113 1990 8 11060 https://doi.org/10.1007/BF00177833 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177833 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tomita Tadanori Division of Pediatric Neurosurgery, Children's Memorial Hospital, 2300 N. Children's Plaza, 60614, Chicago, Il, USA aut NATIONALLICENCE 700 1- Das Lakshmi Division of hematology/Oncology, Children's Memorial Hospital, Illinois, USA aut NATIONALLICENCE 700 1- Radkowski Mary Department of Radiology, Children's Memorial Hospital, Illinois, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 8/2(1990-04-01), 113-120 0167-594X 8:2<113 1990 8 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer