caa a22 4500 465735762 CHVBK 20180323111754.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00177839 doi (NATIONALLICENCE)springer-10.1007/BF00177839 Cerebral diaschisis in patients with malignant glioma [Elektronische Daten] [Jack Rozental, Ross Levine, Robert Nickles, Jeffrey Dobkin, Joan Hanson] A positron emission tomography study using [18F]-fluorodeoxyglucose was undertaken to identify and quantitate whether diaschisis occurred in cerebral cortex, basal ganglia, or thalamus, as well as in cerebellar cortex and dentate nuclei in patients with malignant glioma. The relationship between diaschisis in these cerebral structures and clinically significant hemiparesis in patients was analysed. A 30% decrease in the regional metabolic rate for glucose in the cerebellar hemisphere contralateral to the tumor, and ipsilateral to the motor deficit, was identified and was statistically significant (p > 0.001). Decreased metabolism in the cerebellar hemisphere contralateral to the tumor was not seen in patients without hemiparesis. Parietal lobes affected by tumor had a larger decrease in metabolism than did frontal lobes with tumor (p > 0.01). The overall metabolism of the unaffected cerebellar hemisphere, relative to the peak metabolic activity of the brain, was not depressed in patients with tumor. In addition, the activity of subcortical nuclei was relatively unaffected by adjacent tumor or motor deficit. Kluwer Academic Publishers, 1990 malignant glioma nationallicence diaschisis nationallicence PET scan nationallicence cerebellum nationallicence basal ganglia nationallicence Rozental Jack Neurology and Research Services, Wm. S. Middleton Memorial Veterans Administration Hospital, 53705, Madison, WI aut Levine Ross Neurology and Research Services, Wm. S. Middleton Memorial Veterans Administration Hospital, 53705, Madison, WI aut Nickles Robert Departments of Medical Physics and Radiology, University of Wisconsin, 53705, Madison, WI, USA aut Dobkin Jeffrey Division of Nuclear Medicine, Wm. S. Middleton Memorial Veterans Administration Hospital, 53705, Madison, WI, USA aut Hanson Joan Neurology and Research Services, Wm. S. Middleton Memorial Veterans Administration Hospital, 53705, Madison, WI, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 8/2(1990-04-01), 153-161 0167-594X 8:2<153 1990 8 11060 https://doi.org/10.1007/BF00177839 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177839 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rozental Jack Neurology and Research Services, Wm. S. Middleton Memorial Veterans Administration Hospital, 53705, Madison, WI aut NATIONALLICENCE 700 1- Levine Ross Neurology and Research Services, Wm. S. Middleton Memorial Veterans Administration Hospital, 53705, Madison, WI aut NATIONALLICENCE 700 1- Nickles Robert Departments of Medical Physics and Radiology, University of Wisconsin, 53705, Madison, WI, USA aut NATIONALLICENCE 700 1- Dobkin Jeffrey Division of Nuclear Medicine, Wm. S. Middleton Memorial Veterans Administration Hospital, 53705, Madison, WI, USA aut NATIONALLICENCE 700 1- Hanson Joan Neurology and Research Services, Wm. S. Middleton Memorial Veterans Administration Hospital, 53705, Madison, WI, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 8/2(1990-04-01), 153-161 0167-594X 8:2<153 1990 8 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer