caa a22 4500 465735797 CHVBK 20180323111754.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00177835 doi (NATIONALLICENCE)springer-10.1007/BF00177835 Investigation of an inhibitor of lipid peroxidation U74006F on tumor growth and protein extravasation in the C6 astrocytoma spheroid implantation glioma model [Elektronische Daten] [Joseph Megyesi, Catherine Farrell, Rolando Del Maestro] Summary: The role played by lipid peroxidation in cerebral tumor growth and protein extravasation has not been defined. A potent in vitro inhibitor of lipid peroxidation (21-[4-2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-16a-methylpregna-1,4,9(11)-triene-3,20-dione monomethane sulfonate (U74006F), has been used to assess its influence on both tumor growth and protein extravasation in a rat C6 astrocytoma implantation model. Following spheroid implantation, rats were treated with one of these U74006F regimens: 12 mg/kg/day for 13 days post-implantation, 3.6 mg/kg/day for 13 days post-implantation or 12 mg/kg/day commencing seven days post-implantation until 13 days post-implantation. Tumor wet weights, dry weights and protein flux as measured by Evans blue dye extravasation were assessed. Neither wet weights nor dry weights of any of the three treatment groups was significantly lower when compared to control tumor wet weights and dry weights. Protein extravasation was not significantly reduced by any of the treatments. It is concluded that U74006F did not significantly decrease tumor growth or permeability in the C6 astrocytoma spheroid implantation model. Kluwer Academic Publishers, 1990 edema nationallicence lipid peroxidation nationallicence U74006F nationallicence glioma nationallicence rat nationallicence Megyesi Joseph Brain Research Laboratories, Experimental Research Unit, Departments of Clinical Neurological Sciences, Biochemistry and Biophysics, University of Western Ontario, Victoria Hospital, London, Ontario, Canada aut Farrell Catherine Brain Research Laboratories, Experimental Research Unit, Departments of Clinical Neurological Sciences, Biochemistry and Biophysics, University of Western Ontario, Victoria Hospital, London, Ontario, Canada aut Del Maestro Rolando Brain Research Laboratories, Experimental Research Unit, Departments of Clinical Neurological Sciences, Biochemistry and Biophysics, University of Western Ontario, Victoria Hospital, London, Ontario, Canada aut Journal of Neuro-Oncology Kluwer Academic Publishers 8/2(1990-04-01), 133-137 0167-594X 8:2<133 1990 8 11060 https://doi.org/10.1007/BF00177835 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177835 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Megyesi Joseph Brain Research Laboratories, Experimental Research Unit, Departments of Clinical Neurological Sciences, Biochemistry and Biophysics, University of Western Ontario, Victoria Hospital, London, Ontario, Canada aut NATIONALLICENCE 700 1- Farrell Catherine Brain Research Laboratories, Experimental Research Unit, Departments of Clinical Neurological Sciences, Biochemistry and Biophysics, University of Western Ontario, Victoria Hospital, London, Ontario, Canada aut NATIONALLICENCE 700 1- Del Maestro Rolando Brain Research Laboratories, Experimental Research Unit, Departments of Clinical Neurological Sciences, Biochemistry and Biophysics, University of Western Ontario, Victoria Hospital, London, Ontario, Canada aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 8/2(1990-04-01), 133-137 0167-594X 8:2<133 1990 8 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer