caa a22 4500 465736769 CHVBK 20180323111756.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245750 doi (NATIONALLICENCE)springer-10.1007/BF02245750 Effects of benzodiazepine agonist, inverse agonist and antagonist drugs in the mouse staircase test [Elektronische Daten] [Dimitris Emmanouil, Raymond Quock] This study examined the effects of the benzodiazepine agonist midazolam and inverse agonist noreleagnine independently and in conjunction with the antagonist flumazenil in the mouse staircase test. According to this paradigm, the numbers of steps ascended (NSA) and rears (NR) reflect locomotor activity and anxiety, respectively. Midazolam reduced NR at doses that did not affect NSA; this NR-lowering effect was blocked by flumazenil. Noreleagnine increased NR at doses that did not affect NSA; this NR-elevating effect was also blocked by flumazenil. Effective antagonist doses of flumazenil alone had no effect on NR or NSA. The exactly opposite effects of midazolam and noreleagnine on NR and their antagonism by flumazenil are consistent with the postulated activities of these drugs at benzodiazepine receptors. Springer-Verlag, 1990 Midazolam nationallicence Noreleagnine nationallicence Flumazenil nationallicence Benzodiazepine receptor nationallicence Staircase test nationallicence Mouse nationallicence Emmanouil Dimitris Department of Pediatric Dentistry, Marquette University School of Dentistry, 604 N. 16th Street, 53233-2188, Milwaukee, WI, USA aut Quock Raymond Department of Basic Sciences, Marquette University School of Dentistry, 604 N. 16th Street, 53233-2188, Milwaukee, WI, USA aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 95-97 0033-3158 102:1<95 1990 102 213 https://doi.org/10.1007/BF02245750 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245750 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Emmanouil Dimitris Department of Pediatric Dentistry, Marquette University School of Dentistry, 604 N. 16th Street, 53233-2188, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Quock Raymond Department of Basic Sciences, Marquette University School of Dentistry, 604 N. 16th Street, 53233-2188, Milwaukee, WI, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 95-97 0033-3158 102:1<95 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer