caa a22 4500 465736785 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245753 doi (NATIONALLICENCE)springer-10.1007/BF02245753 Effects of antihistaminics on naloxone-induced withdrawal in morphine-dependent mice [Elektronische Daten] [Juan-Carlos Leza, Ignacio Lizasoain, Pedro Lorenzo] Some histamine H1 (tripelennamine, diphenhydramine and cyclizine) and H2 (ranitidine and cimetidine) antagonists (1 and 10 mg/kg) were administered to morphine — dependent mice to evaluate the changes on naloxone-induced abstinence syndrome. When antihistaminics were administered 30 min before naloxone (1 mg/kg) on day 4 of morphine addiction, the two doses of the three H1 antagonists and the higher dose of ranitidine inhibited shaking behavior. Furthermore, the two doses of tripelennamine and the higher dose of diphenhydramine, cyclizine and cimetidine enhanced jumping behavior. When antihistaminics were administered chronically (during the 4 days of morphine addiction), tripelennamine, cyclizine and ranitidine (all at 10 mg/kg) inhibited shaking behavior. The three H1 antihistaminics used enhanced the number of jumps per mouse whereas ranitidine decreased this response. No significant changes were found in the rest of the withdrawal symptoms after the antihistaminics were administered. The participation of serotonergic and catecholaminergic mechanisms is discussed. Springer-Verlag, 1990 Histamine H1 antagonists nationallicence Histamine H2 antagonists nationallicence Morphine dependence nationallicence Morphine abstinence nationallicence Wet dog shakes nationallicence Jumping nationallicence Leza Juan-Carlos Departamento de Framacologia, Facultad de Medicina, Universidad Complutense, E-28040, Madrid, Spain aut Lizasoain Ignacio Departamento de Framacologia, Facultad de Medicina, Universidad Complutense, E-28040, Madrid, Spain aut Lorenzo Pedro Departamento de Framacologia, Facultad de Medicina, Universidad Complutense, E-28040, Madrid, Spain aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 106-111 0033-3158 102:1<106 1990 102 213 https://doi.org/10.1007/BF02245753 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245753 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Leza Juan-Carlos Departamento de Framacologia, Facultad de Medicina, Universidad Complutense, E-28040, Madrid, Spain aut NATIONALLICENCE 700 1- Lizasoain Ignacio Departamento de Framacologia, Facultad de Medicina, Universidad Complutense, E-28040, Madrid, Spain aut NATIONALLICENCE 700 1- Lorenzo Pedro Departamento de Framacologia, Facultad de Medicina, Universidad Complutense, E-28040, Madrid, Spain aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 106-111 0033-3158 102:1<106 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer