caa a22 4500 465736793 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245741 doi (NATIONALLICENCE)springer-10.1007/BF02245741 Acute and chronic effects of cocaine on isolation-induced aggression in mice [Elektronische Daten] [Nissar Darmani, M. Gary Hadfield, Walter Carter Jr., Billy Martin] The purpose of the present study was to investigate the effects of acute and chronic cocaine administration on aggressive behaviour in mice. The animals were made more aggressive by individual housing for a period of 6 weeks. Group-housed anosmic conspecifics which were not aggressive were used as intruder controls. In acute studies, cocaine induced no significant change in aggressive behaviour at low doses (0.5-5 mg/kg) but significantly decreased aggressive behaviour after doses of 10 and 20 mg/kg. Cocaine increased the isolation-induced aggressive behaviour in mice when they were injected twice daily for a week with low doses of 0.5 or 1 mg/kg. In particular, the latency to first attack was significantly decreased by the drug and the frequency of attack towards the non-aggressive intruder was dramatically increased. Higher cocaine doses (10 or 20 mg/kg) under the described treatment regimen decreased these agonistic repertories. Tolerance did not develop to the anti-aggressive effects of high doses of cocaine on continued treatment. Springer-Verlag, 1990 Cocaine nationallicence Acute nationallicence Chronic nationallicence Aggression nationallicence Tolerance nationallicence Darmani Nissar Department of Pharmacology and Toxicology, Virginia Commonwealth University, 23298, Richmond, VA, USA aut Gary Hadfield M. Department of Pathology, Virginia Commonwealth University, 23298, Richmond, VA, USA aut Carter Jr. Walter Department of Biostatistics, Medical College of Virginia, Virginia Commonwealth University, 23298, Richmond, VA, USA aut Martin Billy Department of Pharmacology and Toxicology, Virginia Commonwealth University, 23298, Richmond, VA, USA aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 37-40 0033-3158 102:1<37 1990 102 213 https://doi.org/10.1007/BF02245741 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245741 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Darmani Nissar Department of Pharmacology and Toxicology, Virginia Commonwealth University, 23298, Richmond, VA, USA aut NATIONALLICENCE 700 1- Gary Hadfield M. Department of Pathology, Virginia Commonwealth University, 23298, Richmond, VA, USA aut NATIONALLICENCE 700 1- Carter Jr Walter Department of Biostatistics, Medical College of Virginia, Virginia Commonwealth University, 23298, Richmond, VA, USA aut NATIONALLICENCE 700 1- Martin Billy Department of Pharmacology and Toxicology, Virginia Commonwealth University, 23298, Richmond, VA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 37-40 0033-3158 102:1<37 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer