caa a22 4500 465736815 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245747 doi (NATIONALLICENCE)springer-10.1007/BF02245747 Serotonin 5-HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder [Elektronische Daten] [Anat Biegon, Nir Essar, Malka Israeli, Avner Elizur, Shlomo Bruch, Aliezer Bar-Nathan] Serotonin receptors of the 5-HT2 type were studied on platelet membranes from 15 patients suffering from major depression. Receptor binding and clinical state (assessed by the Hamilton and Beck rating scales) were examined in a drug free state upon admission and after 1 and 3 weeks of treatment with the antidepressant maprotiline (MPT). 5-HT2 receptor binding changed in correlation with changes in the clinical state of the patients as judged by the rating scales. Since most patients showed a clinical improvement, the patients as a group exhibited a significant decrease in binding concomitant with a drop in depression scores. However, in those patients in whom there was no clinical change or an increase in depression scores, 5-HT2 receptor binding did not change or increased, respectively, thus resulting in a significant correlation between clinical changes and changes in binding. These results support the use of 5-HT2 receptors on platelets in evaluating depression and its treatment. Springer-Verlag, 1990 Serotonin nationallicence Platelets nationallicence Depression nationallicence 5-HT2 receptors nationallicence Maprotiline nationallicence Biegon Anat Weizman Institute of Science, Rehovot, Israel aut Essar Nir Abarbenael Mental Health Center, Bat-Yam, Israel aut Israeli Malka Weizman Institute of Science, Rehovot, Israel aut Elizur Avner Abarbenael Mental Health Center, Bat-Yam, Israel aut Bruch Shlomo Abarbenael Mental Health Center, Bat-Yam, Israel aut Bar-Nathan Aliezer Department of Psychiatry, Tel Aviv Medical Center, Tel Aviv, Israel aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 73-75 0033-3158 102:1<73 1990 102 213 https://doi.org/10.1007/BF02245747 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245747 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Biegon Anat Weizman Institute of Science, Rehovot, Israel aut NATIONALLICENCE 700 1- Essar Nir Abarbenael Mental Health Center, Bat-Yam, Israel aut NATIONALLICENCE 700 1- Israeli Malka Weizman Institute of Science, Rehovot, Israel aut NATIONALLICENCE 700 1- Elizur Avner Abarbenael Mental Health Center, Bat-Yam, Israel aut NATIONALLICENCE 700 1- Bruch Shlomo Abarbenael Mental Health Center, Bat-Yam, Israel aut NATIONALLICENCE 700 1- Bar-Nathan Aliezer Department of Psychiatry, Tel Aviv Medical Center, Tel Aviv, Israel aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 73-75 0033-3158 102:1<73 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer