caa a22 4500 465736831 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245739 doi (NATIONALLICENCE)springer-10.1007/BF02245739 Characterisation of dyskinesias induced by l -dopa in MPTP-treated squirrel monkeys [Elektronische Daten] [S. Boyce, N. Rupniak, M. Steventon, S. Iversen] Intermittent treatment withl-dopa over a 2-year period induced abnormal involuntary movements in MPTP-treated squirrel monkeys. Dyskinesias included a choreic and dystonic component. Dose-response curves for chorea and dystonia revealed that the same dose ofl-dopa (30 mg/kg) induced the highest score for both dyskinesias; however, the severity was much greater for chorea. Choreic movements were always most prevalent at the time of peak effect, whereas dystonia was apparent at the time of peak effect and at "end-of-dose”, and was occasionally observed spontaneously. Our findings indicate that squirrel monkeys treated with MPTP developl-dopa-induced dyskinesias which closely resemble those observed in Parkinson's disease. This species provides a valuable animal model to develop improved therapeutic agents. Springer-Verlag, 1990 l -dopa nationallicence Chorea nationallicence Dystonia nationallicence Parkinson's disease nationallicence Squirrel monkey nationallicence Boyce S. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, CM20 2QR, Harlow, Essex, UK aut Rupniak N. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, CM20 2QR, Harlow, Essex, UK aut Steventon M. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, CM20 2QR, Harlow, Essex, UK aut Iversen S. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, CM20 2QR, Harlow, Essex, UK aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 21-27 0033-3158 102:1<21 1990 102 213 https://doi.org/10.1007/BF02245739 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245739 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boyce S. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, CM20 2QR, Harlow, Essex, UK aut NATIONALLICENCE 700 1- Rupniak N. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, CM20 2QR, Harlow, Essex, UK aut NATIONALLICENCE 700 1- Steventon M. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, CM20 2QR, Harlow, Essex, UK aut NATIONALLICENCE 700 1- Iversen S. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, CM20 2QR, Harlow, Essex, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 21-27 0033-3158 102:1<21 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer