caa a22 4500 46573684X CHVBK 20180323111757.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245746 doi (NATIONALLICENCE)springer-10.1007/BF02245746 Smoking-associated changes in the serotonergic systems of discrete regions of human brain [Elektronische Daten] [Maureen Benwell, David Balfour, John Anderson] This paper describes the results of a postmortem study of the effects of tobacco smoking on the concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) as well as the binding of [3H]-8-hydroxy-(di-n-propylamino)-tetralin ([3H]-8-OH-DPAT) and [3H]-ketanserin in six discrete regions of human brain. Smoking was associated with significant decreases in the concentrations of 5-HIAA in the hippocampal neocortex (P < 0.001), hippocampal formation (P < 0.05) and the median raphe nuclei (P < 0.05). The 5-HT level of the hippocampal formation was also significantly reduced in smokers (P < 0.05). These changes were accompanied by significant increases in the binding of [3H]-8-OH-DPAT in the hippocampal neocortex (P < 0.01) and hippocampal formation (P < 0.05). [3H]-Ketanserin binding in the brain regions studied was unaffected by smoking. It is concluded that smoking is associated with a regionally selective decrease in the activity of the serotonergic system of the human hippocampus. Springer-Verlag, 1990 Tobacco smoking nationallicence Human brain nationallicence 5-Hydroxytryptamine nationallicence 8-OH-DPAT binding nationallicence Ketanserin binding nationallicence Hippocampus nationallicence Benwell Maureen Department of Pharmacology and Clinical Pharmacology, University Medical School Ninewells Hospital, DD1 9SY, Dundee, Scotland, UK aut Balfour David Department of Pharmacology and Clinical Pharmacology, University Medical School Ninewells Hospital, DD1 9SY, Dundee, Scotland, UK aut Anderson John Department of Pathology, University Medical School Ninewells Hospital, DD1 9SY, Dundee, Scotland, UK aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 68-72 0033-3158 102:1<68 1990 102 213 https://doi.org/10.1007/BF02245746 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245746 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Benwell Maureen Department of Pharmacology and Clinical Pharmacology, University Medical School Ninewells Hospital, DD1 9SY, Dundee, Scotland, UK aut NATIONALLICENCE 700 1- Balfour David Department of Pharmacology and Clinical Pharmacology, University Medical School Ninewells Hospital, DD1 9SY, Dundee, Scotland, UK aut NATIONALLICENCE 700 1- Anderson John Department of Pathology, University Medical School Ninewells Hospital, DD1 9SY, Dundee, Scotland, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 68-72 0033-3158 102:1<68 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer