caa a22 4500 465736858 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245736 doi (NATIONALLICENCE)springer-10.1007/BF02245736 Behavioral sensitization to beta-phenylethylamine (PEA): enduring modifications of specific dopaminergic neuron systems in the rat [Elektronische Daten] [Toshihide Kuroki, Tetsuyuki Tsutsumi, Makoto Hirano, Takashi Matsumoto, Yoshihiro Tatebayashi, Kohji Nishiyama, Hideyuki Uchimura, Akio Shiraishi, Tatsuo Nakahara, Kaoru Nakamura] Repeated daily administration of an endogenous trace amine, beta-phenylethylamine (PEA), produces behavioral sensitization such that the intensity of PEA-induced stereotyped behaviors in rats increases gradually during the treatment, and a challenge injection with PEA reinstates the enhanced stereotypy even long after withdrawal. In the present study, we examined the neurochemical changes in the central dopaminergic neuron systems in the rat for 7 drug-free days after repeated treatment with PEA (50 mg/kg, IP day for 14 or 28 days). During withdrawal, a decrease in steady-state levels of tissue dopamine (DA) and its metabolite, dihydroxyphenylacetic acid (DOPAC), was found in the mesolimbic DA nerve terminal areas of the rat brain receiving repeated PEA treatment. Fifteen minutes after challenge administration of PEA at varying doses from 6.3 to 75 mg/kg, the rats with repeated PEA treatment required smaller doses of PEA challenge than the rats with acute PEA treatment in order to obtain a significant decrease in striatal DOPAC content compared to the saline control in each treatment group. These results imply that the behavioral sensitization to PEA is accompanied by enduring modifications of the specific dopaminergic neuron systems in the rat brain. This suggestion was strongly supported by the results of the study using in vivo intracerebral dialysis, which indicated that 25 mg/kg PEA challenge elicited a remarkable increase in the extracellular DA concentrations in striatal perfusates collected from the PEA-pretreated rats, in accordance with the intensity of stereotyped behaviors. These findings argue that the hyper-responsiveness to PEA of the striatal dopaminergic neuron systems persists long after withdrawal from repeated treatment with PEA. Springer-Verlag, 1990 Beta-phenylethylamine nationallicence Stereotypy nationallicence Behavioral sensitization nationallicence Dopamine nationallicence Striatum nationallicence Rat nationallicence PEA : beta-phenylethylamine nationallicence DA : dopamine nationallicence DOPAC : dihydroxyphenylacetic acid nationallicence HVA : homovanillic acid nationallicence HPLC-ECD : high performance liquid chromatography with electrochemical detection nationallicence Kuroki Toshihide Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut Tsutsumi Tetsuyuki Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut Hirano Makoto Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut Matsumoto Takashi Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut Tatebayashi Yoshihiro Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut Nishiyama Kohji Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut Uchimura Hideyuki Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut Shiraishi Akio Department of Biology, Kyushu University, Hakozaki, Higashiku, 812, Fukuoka, Japan aut Nakahara Tatsuo Department of Chemistry, Faculty of Science, Kyushu University, Hakozaki, Higashiku, 812, Fukuoka, Japan aut Nakamura Kaoru Department of Neuropsychiatry, Omuta Rousai Hospital, 837, Yoshino, Omuta, Japan aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 5-10 0033-3158 102:1<5 1990 102 213 https://doi.org/10.1007/BF02245736 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245736 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuroki Toshihide Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut NATIONALLICENCE 700 1- Tsutsumi Tetsuyuki Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut NATIONALLICENCE 700 1- Hirano Makoto Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut NATIONALLICENCE 700 1- Matsumoto Takashi Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut NATIONALLICENCE 700 1- Tatebayashi Yoshihiro Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut NATIONALLICENCE 700 1- Nishiyama Kohji Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut NATIONALLICENCE 700 1- Uchimura Hideyuki Laboratory of Neurochemistry. Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki, Saga, Japan aut NATIONALLICENCE 700 1- Shiraishi Akio Department of Biology, Kyushu University, Hakozaki, Higashiku, 812, Fukuoka, Japan aut NATIONALLICENCE 700 1- Nakahara Tatsuo Department of Chemistry, Faculty of Science, Kyushu University, Hakozaki, Higashiku, 812, Fukuoka, Japan aut NATIONALLICENCE 700 1- Nakamura Kaoru Department of Neuropsychiatry, Omuta Rousai Hospital, 837, Yoshino, Omuta, Japan aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 5-10 0033-3158 102:1<5 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer