caa a22 4500 465736904 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245756 doi (NATIONALLICENCE)springer-10.1007/BF02245756 Chronic low-dose haloperidol effects on self-stimulation rate-intensity functions [Elektronische Daten] [Minda Lynch, Robert Carey] Animals responding for biphasic square wave stimulation to the VTA were treated for 26 days with a low dose (0.07 mg/kg) of the neuroleptic haloperidol and tested at 1 h post-injection. Initially the drug induced a pronounced lateral displacement of the baseline rate-intensity function, concomitant with a depression in slope. Over the course of chronic treatment, partial tolerance was observed to the drug-induced increases in threshold concomitant with the onset of a significant suppression in peak response rate. Biochemical tolerance to stimulated dopamine metabolism (as per cent non-drug control) was significant only for mesolimbic (versus neostriatal) regions, in animals receiving haloperidol according to pre- and post-test administration schedules. The observation of sensitization to peak rate reductions parallels previous reports for spontaneous locomotor activity measures and is compatible with depolarization inactivation mechanisms proposed to account for delayed-onset clinical effects. Further, selective biochemical tolerance in mesolimbic regions supports suggestions that mesolimbic dopamine is important as a substrate for subtle low dose neuroleptic effects which may be relevant for studying pharmacotherapeutic treatment issues. Springer-Verlag, 1990 Neuroleptics nationallicence Tolerance nationallicence Sensitization nationallicence Self-stimulation nationallicence Dopamine nationallicence Lynch Minda Department of Psychiatry, SUNY Health Science Center and Research and Development Service, V.A. Medical Center, 800 Irving Avenue, 13210, Syracuse, NY, USA aut Carey Robert Department of Psychiatry, SUNY Health Science Center and Research and Development Service, V.A. Medical Center, 800 Irving Avenue, 13210, Syracuse, NY, USA aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 122-129 0033-3158 102:1<122 1990 102 213 https://doi.org/10.1007/BF02245756 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245756 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lynch Minda Department of Psychiatry, SUNY Health Science Center and Research and Development Service, V.A. Medical Center, 800 Irving Avenue, 13210, Syracuse, NY, USA aut NATIONALLICENCE 700 1- Carey Robert Department of Psychiatry, SUNY Health Science Center and Research and Development Service, V.A. Medical Center, 800 Irving Avenue, 13210, Syracuse, NY, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 122-129 0033-3158 102:1<122 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer