caa a22 4500 465736912 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245737 doi (NATIONALLICENCE)springer-10.1007/BF02245737 Role of initial sensitivity and genetic factors in the development of tolerance to ethanol in AT and ANT rats [Elektronische Daten] [A. Lê, K. Kiianmaa] The role of initial sensitivity and genetic factors in the development of tolerance to ethanol were examined in rats selected for low (AT) and high (ANT) sensitivity to the motor impairment effect of ethanol. Following chronic ethanol treatment (5 g/kg PO, daily for 20 days), the AT and ANT rats acquired tolerance to the motor impairment effect of ethanol at a similar rate. The AT rats, however, acquired tolerance to the hypothermic effect of ethanol at a higher rate than the ANT rats. Such ethanol treatment did not produce any metabolic tolerance to ethanol in these animals. Since there is no difference in the initial response to the hypothermic effect of ethanol between the AT and ANT rats, the observed differences in the rate of tolerance development might be related to a direct genetic factor. The similar rate of tolerance development to the motor impairment effect of ethanol between the two lines was attributed to an interaction between an indirect (initial sensitivity) and a genetic factor in tolerance development. Springer-Verlag, 1990 Genetically selected rat lines nationallicence Ethanol nationallicence Tolerance nationallicence Initial sensitivity nationallicence Genetic nationallicence Lê A. Addiction Research Foundation of Ontario, M5S 2S1, Toronto, Ontario, Canada aut Kiianmaa K. Research Laboratories of the Finnish State Alcohol Company (ALKO Ltd), P.O. Box 350, SF-00101, Helsinki, Finland aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 11-16 0033-3158 102:1<11 1990 102 213 https://doi.org/10.1007/BF02245737 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245737 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lê A. Addiction Research Foundation of Ontario, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Kiianmaa K. Research Laboratories of the Finnish State Alcohol Company (ALKO Ltd), P.O. Box 350, SF-00101, Helsinki, Finland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 11-16 0033-3158 102:1<11 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer