caa a22 4500 465736939 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245757 doi (NATIONALLICENCE)springer-10.1007/BF02245757 Opposing effects of vasopressin on matching versus non-matching to position: further evidence for response, not memory, modulation [Elektronische Daten] [A. Saghal, A. Keith, S. Lloyd] Rats were trained on either of two related variants of an operant memory task. In the matching to position (MTP) task, one of two retractable response levers appeared, at random, as the sample. A response caused the lever to retract and this was followed by a delay (0-32 s) interval, during which the subjects had to approach and respond at the magazine tray. Both levers were then presented and the rat had to respond, for food reward, to the one which had appeared as the sample. A second group of rats learned non-matching to position (NMTP). This task was very similar to MTP, with one crucial difference: here, the subject had to respond to the lever which hadnot appeared as the sample. Both groups of rats learned their respective tasks rapidly, performance depending on the delay interval as expected. They were then injected, peripherally, with different doses of arginine-vasopressin (AVP: 0-25 µg/kg), a peptide which others have argued improves mnemonic performance. There was evidence to suggest that MTP performance was improved by AVP; on the other hand, NMTP performance appeared to be disrupted. It is suggested that AVP induces a bias towards responding on one side of the two lever test chamber. In other words, it affects motor or motivational, not mnemonic mechanisms. Springer-Verlag, 1990 Vasopressin nationallicence Matching to position nationallicence Non-matching to position nationallicence Memory nationallicence Bias nationallicence Rat nationallicence Saghal A. MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle-upon-Tyne, UK aut Keith A. MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle-upon-Tyne, UK aut Lloyd S. MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle-upon-Tyne, UK aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 130-135 0033-3158 102:1<130 1990 102 213 https://doi.org/10.1007/BF02245757 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245757 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Saghal A. MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle-upon-Tyne, UK aut NATIONALLICENCE 700 1- Keith A. MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle-upon-Tyne, UK aut NATIONALLICENCE 700 1- Lloyd S. MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle-upon-Tyne, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 130-135 0033-3158 102:1<130 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer