caa a22 4500 465736947 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245754 doi (NATIONALLICENCE)springer-10.1007/BF02245754 Peak B endorphin concentration in cerebrospinal fluid: reduced in chronic pain patients and increased during the placebo response [Elektronische Daten] [Jonathan Lipman, Barney Miller, Kit Mays, Merry Miller, William North, William Byrne] The level of an endogenous opioid (peak B endorphin) was measured in chromatographically fractionated cerebrospinal fluid (CSF) sampled from two groups of chronic pain patients before and after intrathecal saline (placebo) injection. As assessed by a verbal rating scale, one group reported no change in their level of pain (non-responders, NR;n=6) while the other group reported complete or >50% pain relief (placebo responders, PR;n=14). We find, as has been reported previously, that initial peak B levels were lower (by 50%) in these chronic pain patients' CSF than in CSF from pain-free (PF) normal controls (P<0.001,t-test). Peak B levels measured from CSF of the NR group undergoing this procedure did not change (P>0.4, pairedt-test). In contrast, a significant 2.3-fold increase was measured in the CSF peak B level of the PR group (P<0.05, pairedt-test). This is the first direct evidence that a CSF opioid is correlated with placebo pain relief in chronic pain patients. Peak B is a potent analgesic substance when administered by the intracerebroventricular route in mice and its level is related to the patients' pain status in a presumably causal manner. Springer-Verlag, 1990 Chronic pain nationallicence Peak B nationallicence Endogenous opioid nationallicence Endorphin nationallicence Analgesia nationallicence Placebo nationallicence Cerebrospinal fluid nationallicence Lipman Jonathan Department of Biochemistry, University of Tennessee Center for the Health Sciences, 38163, Memphis, TN, USA aut Miller Barney Department of Biochemistry, University of Tennessee Center for the Health Sciences, 38163, Memphis, TN, USA aut Mays Kit Department of Anesthesiology, University of Tennessee Center for the Health Sciences, 38163, Memphis, TN, USA aut Miller Merry Department of Biochemistry, University of Tennessee Center for the Health Sciences, 38163, Memphis, TN, USA aut North William Department of Anesthesiology, University of Tennessee Center for the Health Sciences, 38163, Memphis, TN, USA aut Byrne William Department of Biochemistry, University of Tennessee Center for the Health Sciences, 38163, Memphis, TN, USA aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 112-116 0033-3158 102:1<112 1990 102 213 https://doi.org/10.1007/BF02245754 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245754 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lipman Jonathan Department of Biochemistry, University of Tennessee Center for the Health Sciences, 38163, Memphis, TN, USA aut NATIONALLICENCE 700 1- Miller Barney Department of Biochemistry, University of Tennessee Center for the Health Sciences, 38163, Memphis, TN, USA aut NATIONALLICENCE 700 1- Mays Kit Department of Anesthesiology, University of Tennessee Center for the Health Sciences, 38163, Memphis, TN, USA aut NATIONALLICENCE 700 1- Miller Merry Department of Biochemistry, University of Tennessee Center for the Health Sciences, 38163, Memphis, TN, USA aut NATIONALLICENCE 700 1- North William Department of Anesthesiology, University of Tennessee Center for the Health Sciences, 38163, Memphis, TN, USA aut NATIONALLICENCE 700 1- Byrne William Department of Biochemistry, University of Tennessee Center for the Health Sciences, 38163, Memphis, TN, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 112-116 0033-3158 102:1<112 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer