caa a22 4500 465736971 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245758 doi (NATIONALLICENCE)springer-10.1007/BF02245758 Super-reactivity to amphetamine toxicity induced by schedule of reinforcement [Elektronische Daten] [Matilde Valencia-Flores, David Velázquez-Martínez, Julían Villarreal] The chronic exposure of rats to a schedule of operant water reinforcement coupled with chronically restricted access to water sensitized the animals to intermittentd-amphetamine injections (0.31-2.5 mg/kg with intervals of 12-23 days between any two injections) in such a way that this drug came to produce catastrophic losses of body weight (32.4% of control levels). In the sessions whend-amphetamine was administered, the rats were also given a total of 12 brief electric shocks. Loss of body weight was unaccompanied by parallel changes in operant behavior performance, or in food or water intake. Remarkably, in other studies with the same interventions (sham schedule sessions, water deprivation, and foot shocks), with the exception that reinforcers were never delivered,d-amphetamine did not produce catastrophic falls in body weight. This super-reactivity tod-amphetamine toxicity may be mediated by a possible stressor action of the schedule of reinforcement. Its mechanism might be analogous to the known sensitization produced by classical experimental stressor stimuli to the repeated administration ofd-amphetamine. Springer-Verlag, 1990 Schedule effects nationallicence Amphetamine toxicity nationallicence Body weight loss nationallicence Drug-behavior interactions nationallicence Water deprivation nationallicence Valencia-Flores Matilde Departamento de Psicofisiología, Facultad de Psicología and Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico aut Velázquez-Martínez David Departamento de Psicofisiología, Facultad de Psicología, Universidad Nacional Autónoma de México, Mexico aut Villarreal Julían Departamento de Farmacología y Toxicología del Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Mexico aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 136-144 0033-3158 102:1<136 1990 102 213 https://doi.org/10.1007/BF02245758 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245758 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Valencia-Flores Matilde Departamento de Psicofisiología, Facultad de Psicología and Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico aut NATIONALLICENCE 700 1- Velázquez-Martínez David Departamento de Psicofisiología, Facultad de Psicología, Universidad Nacional Autónoma de México, Mexico aut NATIONALLICENCE 700 1- Villarreal Julían Departamento de Farmacología y Toxicología del Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Mexico aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 136-144 0033-3158 102:1<136 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer