caa a22 4500 46573698X CHVBK 20180323111757.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02245735 doi (NATIONALLICENCE)springer-10.1007/BF02245735 Apomorphine disrupts the inhibition of acoustic startle induced by weak prepulses in rats [Elektronische Daten] [Michael Davis, Robert Mansbach, Neal Swerdlow, Serge Campeau, David Braff, Mark Geyer] Separate experiments conducted in two different laboratories assessed the importance of the prepulse intensity in the ability of apomorphine to reduce prepulse inhibition of acoustic startle responses. Rats were presented with noise bursts alone or noise bursts 100 ms after presentation of prepulse stimuli ranging from 70 to 85 or 90 dB. Throughout testing, the background noise was maintained at 65 dB. In both laboratories, apomorphine markedly decreased the absolute magnitude of prepulse inhibition when the prepulse stimuli were no more than 10 dB above the background. With more intense prepulse stimuli, apomorphine had no significant effect on prepulse inhibition. Hence, apomorphine does not interfere with the inhibitory process which actually mediates prepulse inhibition, but appears to affect the detectability of the prepulse. Springer-Verlag, 1990 Apomorphine nationallicence Startle nationallicence Prepulse inhibition nationallicence Davis Michael Department of Psychiatry, Yale University, 34 Park Street, 06508, New Haven, CT, USA aut Mansbach Robert Department of Psychiatry, University of California at San Diego, San Diego, USA aut Swerdlow Neal Department of Psychiatry, University of California at San Diego, San Diego, USA aut Campeau Serge Department of Psychiatry, Yale University, 34 Park Street, 06508, New Haven, CT, USA aut Braff David Department of Psychiatry, University of California at San Diego, San Diego, USA aut Geyer Mark Department of Psychiatry, University of California at San Diego, San Diego, USA aut Psychopharmacology Springer-Verlag 102/1(1990-09-01), 1-4 0033-3158 102:1<1 1990 102 213 https://doi.org/10.1007/BF02245735 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245735 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Davis Michael Department of Psychiatry, Yale University, 34 Park Street, 06508, New Haven, CT, USA aut NATIONALLICENCE 700 1- Mansbach Robert Department of Psychiatry, University of California at San Diego, San Diego, USA aut NATIONALLICENCE 700 1- Swerdlow Neal Department of Psychiatry, University of California at San Diego, San Diego, USA aut NATIONALLICENCE 700 1- Campeau Serge Department of Psychiatry, Yale University, 34 Park Street, 06508, New Haven, CT, USA aut NATIONALLICENCE 700 1- Braff David Department of Psychiatry, University of California at San Diego, San Diego, USA aut NATIONALLICENCE 700 1- Geyer Mark Department of Psychiatry, University of California at San Diego, San Diego, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/1(1990-09-01), 1-4 0033-3158 102:1<1 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer