caa a22 4500 465737013 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244111 doi (NATIONALLICENCE)springer-10.1007/BF02244111 Extinction and reacquisition of differential responding in rats trained to discriminate between chlordiazepoxide and saline [Elektronische Daten] [Henk Rijnders, Torbjörn Järbe, Jef Slangen] In order to assess the resistance of drug discriminative responding to prolonged reinforcement omission, rats were trained to discriminate between either 6.0 mg/kg PO or 30.0 mg/kg PO. CDP and saline, using a food reinforced (VI40-FR10) operant procedure. Dose generalization tests were conducted for both groups. Sessions were then run without reinforcement while drug (D) and saline (S) administrations were continued (extinction phase). After a maximum of 30 sessions without reinforcement, or when the rats emitted less than ten responses on either lever during three successive sessions (extinction criterion), reinforcement was reinstated. Finally, additional dose generalization tests with CDP were run. The discriminative responding controlled by the D and S administrations was not affected significantly by prolonged reinforcement omission in either group. For both groups, response rates were decreased and latencies to initiate responding were increased during the extinction phase. Response rate reduction occurred more rapidly for the drug condition in the high training dose group. This group also reached the extinction criterion sooner than the low training dose group. The reacquisition process occurred very rapidly. Response rates increased substantially after the first reinforcement had been obtained. After ten reacquisition sessions, response rates and latencies had reached values similar to those observed before extinction was initiated. Data revealed no differences between groups and the course of reacquisition did not differ between the S and D conditions. The generalization tests executed before the extinction phase and after the reacquisition phase yielded similar results and were in agreement with earlier findings. The major conclusion was that the resistance to extinction of the discriminative accuracy was substantial. Springer-Verlag, 1990 Drug discrimination nationallicence Extinction nationallicence Chlordiazepoxide nationallicence Rats nationallicence Rijnders Henk Faculty of Pharmacy, Psychopharmacology Section, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut Järbe Torbjörn Department of Psychology, University of Uppsala, Sweden aut Slangen Jef Faculty of Pharmacy, Psychopharmacology Section, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut Psychopharmacology Springer-Verlag 102/3(1990-11-01), 404-410 0033-3158 102:3<404 1990 102 213 https://doi.org/10.1007/BF02244111 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244111 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rijnders Henk Faculty of Pharmacy, Psychopharmacology Section, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Järbe Torbjörn Department of Psychology, University of Uppsala, Sweden aut NATIONALLICENCE 700 1- Slangen Jef Faculty of Pharmacy, Psychopharmacology Section, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 404-410 0033-3158 102:3<404 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer