caa a22 4500 465737048 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244099 doi (NATIONALLICENCE)springer-10.1007/BF02244099 Facilitation of memory retrieval by pretest morphine mediated by μ but not δ and κ opioid receptors [Elektronische Daten] [Yasuyuki Shiigi, Masakatsu Takahashi, Hiroshi Kaneto] Mice were trained to avoid electric shock (0.6 mA) in a step-through type passive avoidance learning task, retention being measured 24 h after the training trial. Morphine 10 mg/kg administered 30 min before the test trial (pretest) facilitated memory retrieval, and the effect was completely antagonized by 1 mg/kg naloxone, a selective μ-opioid receptor antagonist. On the other hand, pretest administration of 0.01-10 mg/kg DTLET, a selective δ-opioid receptor agonist, did not produce the same effect as morphine. Nor-binaltorphimine, a κ-opioid receptor antagonist, did not antagonize the effect of pretest morphine, at doses of 1 and 2 mg/kg. These results suggest that the facilitation of memory retrieval by pretest morphine is mediated through μ- but not δ- or κ-opioid receptors. Springer-Verlag, 1990 Morphine nationallicence Passive avoidance nationallicence Memory retrieval nationallicence Opioid receptor nationallicence Mouse nationallicence Shiigi Yasuyuki Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, 852, Nagasaki, Japan aut Takahashi Masakatsu Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, 852, Nagasaki, Japan aut Kaneto Hiroshi Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, 852, Nagasaki, Japan aut Psychopharmacology Springer-Verlag 102/3(1990-11-01), 329-332 0033-3158 102:3<329 1990 102 213 https://doi.org/10.1007/BF02244099 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244099 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shiigi Yasuyuki Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, 852, Nagasaki, Japan aut NATIONALLICENCE 700 1- Takahashi Masakatsu Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, 852, Nagasaki, Japan aut NATIONALLICENCE 700 1- Kaneto Hiroshi Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, 852, Nagasaki, Japan aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 329-332 0033-3158 102:3<329 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer