caa a22 4500 465737080 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244096 doi (NATIONALLICENCE)springer-10.1007/BF02244096 Influence of certain H1-blockers on the step-through active avoidance response in rats [Elektronische Daten] [Chiaki Kamei, Y. Chung, Kenji Tasaka] The inhibitory effects of some newly developed H1-blockers on the step-through active avoidance response in rats were studied in comparison with those of classical H1-blockers. Single administration of diphenhydramine, pyrilamine, promethazine and chlorpheniramine caused dose-related depressant effects on the active avoidance response. Ketotifen and azelastine caused less potent inhibition than the classical H1-blockers, while the effects of astemizole and oxatomide were almost negligible in suppressing the response. Following chronic administration of pyrilamine and promethazine, the acquisition of active avoidance response was significantly retarded compared with the control group, where-as new H1-blockers caused a somewhat but not significantly slower acquisition than the control group. Chronic administration of astemizole and oxatomide caused only transient suppression of the response. However, classical H1-blockers such as pyrilamine and promethazine caused sustained inhibition for as long as drug administration was continued. Springer-Verlag, 1990 H1-blockers nationallicence Active avoidance nationallicence Retention nationallicence Acquisition nationallicence Chronic administration nationallicence Rat nationallicence Kamei Chiaki Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, 700, Okayama, Japan aut Chung Y. Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, 700, Okayama, Japan aut Tasaka Kenji Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, 700, Okayama, Japan aut Psychopharmacology Springer-Verlag 102/3(1990-11-01), 312-318 0033-3158 102:3<312 1990 102 213 https://doi.org/10.1007/BF02244096 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244096 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kamei Chiaki Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, 700, Okayama, Japan aut NATIONALLICENCE 700 1- Chung Y. Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, 700, Okayama, Japan aut NATIONALLICENCE 700 1- Tasaka Kenji Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, 700, Okayama, Japan aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 312-318 0033-3158 102:3<312 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer