caa a22 4500 465737099 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244116 doi (NATIONALLICENCE)springer-10.1007/BF02244116 Effects of scopolamine, trimipramine and diazepam on explicit memory and repetition priming in healthy volunteers [Elektronische Daten] [Jean-Marie Danion, Marie-Agathe Zimmermann, Dominique Willard-Schroeder, Danielle Grangé, Marie Welsch, Jean-Louis Imbs, Léonard Singer] The effects of scopolamine, an anticholinergic drug, of trimipramine, a tricyclic antidepressant with both anticholinergic and sedative properties, of diazepam and a placebo, on explicit memory and repetition priming were assessed using a free-recall task and a word-stem completion task. Forty-eight healthy volunteers took part in this double-blind study. Diazepam provoked a dissociation between free recall, which was profoundly impaired, and word completion, which was spared. No significant changes in memory performances were observed in the scopolamine group; however, a significant correlation between explicit and implicit memory performances was observed in this group. At the low dose used, the effects of trimipramine on memory were mild. The results suggest that the cholinergic system is involved in the priming effect. Springer-Verlag, 1990 Memory nationallicence Human nationallicence Scopolamine nationallicence Antidepressant nationallicence Diazepam nationallicence Danion Jean-Marie Department de Psychiatrie, Centre Hospitalier Universitaire, Hospices Civils, F-67091, Strasbourg, France aut Zimmermann Marie-Agathe Department de Psychiatrie, Centre Hospitalier Universitaire, Hospices Civils, F-67091, Strasbourg, France aut Willard-Schroeder Dominique Department de Psychiatrie, Centre Hospitalier Universitaire, Hospices Civils, F-67091, Strasbourg, France aut Grangé Danielle Unité de Statistiques, Centre de Calcul du CNRS, 23 Rue du Loess, F-67200, Strasbourg, France aut Welsch Marie Institut de Pharmacologie, Unité de Pharmacologie Clinique, Faculté de Médecine, 11 Rue Human, F-67000, Strasbourg, France aut Imbs Jean-Louis Institut de Pharmacologie, Unité de Pharmacologie Clinique, Faculté de Médecine, 11 Rue Human, F-67000, Strasbourg, France aut Singer Léonard Department de Psychiatrie, Centre Hospitalier Universitaire, Hospices Civils, F-67091, Strasbourg, France aut Psychopharmacology Springer-Verlag 102/3(1990-11-01), 422-424 0033-3158 102:3<422 1990 102 213 https://doi.org/10.1007/BF02244116 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244116 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Danion Jean-Marie Department de Psychiatrie, Centre Hospitalier Universitaire, Hospices Civils, F-67091, Strasbourg, France aut NATIONALLICENCE 700 1- Zimmermann Marie-Agathe Department de Psychiatrie, Centre Hospitalier Universitaire, Hospices Civils, F-67091, Strasbourg, France aut NATIONALLICENCE 700 1- Willard-Schroeder Dominique Department de Psychiatrie, Centre Hospitalier Universitaire, Hospices Civils, F-67091, Strasbourg, France aut NATIONALLICENCE 700 1- Grangé Danielle Unité de Statistiques, Centre de Calcul du CNRS, 23 Rue du Loess, F-67200, Strasbourg, France aut NATIONALLICENCE 700 1- Welsch Marie Institut de Pharmacologie, Unité de Pharmacologie Clinique, Faculté de Médecine, 11 Rue Human, F-67000, Strasbourg, France aut NATIONALLICENCE 700 1- Imbs Jean-Louis Institut de Pharmacologie, Unité de Pharmacologie Clinique, Faculté de Médecine, 11 Rue Human, F-67000, Strasbourg, France aut NATIONALLICENCE 700 1- Singer Léonard Department de Psychiatrie, Centre Hospitalier Universitaire, Hospices Civils, F-67091, Strasbourg, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 422-424 0033-3158 102:3<422 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer