caa a22 4500 465737129 CHVBK 20180323111757.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244109 doi (NATIONALLICENCE)springer-10.1007/BF02244109 Ethanol effects on delayed spatial matching as modeled by a negative exponential forgetting function [Elektronische Daten] [Kathleen Melia, George Koob, Cindy Ehlers] Performance on delayed matching-to-position as a function of ethanol was investigated in rats and dose effects assessed by fitting an exponential decay model of forgetting to signal detection sensitivity scores. Three ethanol doses (0.25, 0.50, and 0.75 g/kg) and one isovolume saline control were examined. For further comparison, one dose of chlordiazepoxide (CDP; 5 mg/kg) and its saline control were also given. Forgetting functions were reasonably well described by the decay model under all treatment conditions. In addition, the functions's decay constant (−b) proved to be differentially sensitive to both drug and dose effects. Reduced decay estimates were obtained following the two lowest ethanol doses, the reduction being statistically significant for the 0.25 g/kg dose. In contrast, the function estimate of initial sensitivity, the intercept parameter (SI0), was not significantly affected by ethanol. Consistent with the low-dose ethanol effects, CDP significantly decreased the value of the decay parameter while leaving the intercept parameter unaffected. But unlike ethanol, the variance accounted for by the model for the individual data was less following CDP administration. Drug effects were interpreted using the exponential decay model of forgetting, and the results suggest independent discriminative control over SI0 and b. The significant effect of the low-dose sedative-hypnotics upon b, with no attendant effects upon SI0, is suggested to result from enhanced, spontaneous, delay interval mediation. Springer-Verlag, 1990 Delayed matching-to-position nationallicence Signal detection theory nationallicence Exponential model nationallicence Ethanol nationallicence Chlordiazepoxide nationallicence Rat nationallicence Melia Kathleen Department of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Koob George Department of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Ehlers Cindy Department of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Psychopharmacology Springer-Verlag 102/3(1990-11-01), 391-398 0033-3158 102:3<391 1990 102 213 https://doi.org/10.1007/BF02244109 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244109 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Melia Kathleen Department of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Koob George Department of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Ehlers Cindy Department of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 391-398 0033-3158 102:3<391 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer