caa a22 4500 465737153 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244091 doi (NATIONALLICENCE)springer-10.1007/BF02244091 Antagonism of the anti-conflict effects of phenobarbital, but not diazepam, by the A-1 adenosine agonist l -PIA [Elektronische Daten] [Randall Commissaris, Timothy McCloskey, Gracia Damian, Brian Brown, Robin Barraco, Harvey Altman] The present study examined the effects of the anxiolytics diazepam and phenobarbital, the A-1 adenosine agonist N6-R-phenylisopropyladenosine (l-PIA), and the A-2 adenosine agonist 5′-N-ethylcarboxamidoadenosine (NECA) on conflict behavior. Water-restricted rats were trained to drink from a tube that was electrified (0.5 mA intensity) on a FI-29s schedule, electrification being signaled by a tone. After 3 weeks of daily 10-min sessions, the animals accepted a stable number of shocks (punished responding) and consumed a consistent volume of water (unpunished responding) per session. Different doses ofl-PIA and NECA were then tested separately at weekly intervals. In addition, the effects of diazepam and phenobarbital were determined in animals pretreated with saline,l-PIA, or NECA. Neitherl-PIA (15-250 nmole/kg) nor NECA (2.5-20 nmole/kg) produced a significant anti-conflict effect when administered alone. Diazepam (1.25-10 mg/kg) or phenobarbital (10-40 mg/kg) administration to saline-pretreated rats resulted in a dose-dependent increase in punished responding (shocks received) with minimal effects on unpunished responding (water intake). Neitherl-PIA nor NECA pretreatment reliably altered the effects of diazepam on conflict behavior. Pretreatment withl-PIA, but not NECA, significantly reduced the anti-conflict effects of phenobarbital on conflict behavior. These data suggest that phenobarbital, but not diazepam, anti-conflict responses may involve interactions with A-1 adenosine receptors. Springer-Verlag, 1990 Adenosine nationallicence Anxiety nationallicence Conflict behavior nationallicence Caffeine nationallicence Conditioned Suppression of Drinking (CSD) nationallicence Diazepam nationallicence l -PIA nationallicence NECA nationallicence Phenobarbital nationallicence Rats nationallicence Commissaris Randall Department of Pharmaceutical Sciences, College of Pharmacy & AHP, Wayne State University, 48202, Detroit, MI, USA aut McCloskey Timothy Department of Pharmaceutical Sciences, College of Pharmacy & AHP, Wayne State University, 48202, Detroit, MI, USA aut Damian Gracia Department of Physiology, School of Medicine, Wayne State University, 48202, Detroit, MI, USA aut Brown Brian Department of Pharmaceutical Sciences, College of Pharmacy & AHP, Wayne State University, 48202, Detroit, MI, USA aut Barraco Robin Department of Physiology, School of Medicine, Wayne State University, 48202, Detroit, MI, USA aut Altman Harvey Department of Psychiatry, Wayne State University, 48202, Detroit, MI, USA aut Psychopharmacology Springer-Verlag 102/3(1990-11-01), 283-290 0033-3158 102:3<283 1990 102 213 https://doi.org/10.1007/BF02244091 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244091 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Commissaris Randall Department of Pharmaceutical Sciences, College of Pharmacy & AHP, Wayne State University, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- McCloskey Timothy Department of Pharmaceutical Sciences, College of Pharmacy & AHP, Wayne State University, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Damian Gracia Department of Physiology, School of Medicine, Wayne State University, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Brown Brian Department of Pharmaceutical Sciences, College of Pharmacy & AHP, Wayne State University, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Barraco Robin Department of Physiology, School of Medicine, Wayne State University, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Altman Harvey Department of Psychiatry, Wayne State University, 48202, Detroit, MI, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 283-290 0033-3158 102:3<283 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer