caa a22 4500 465737188 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244098 doi (NATIONALLICENCE)springer-10.1007/BF02244098 Drug-induced purposeless chewing: animal model of dyskinesia or nausea? [Elektronische Daten] [N. Rupniak, S. Tye, S. Iversen] Drug-induced purposeless chewing movements in rodents are often considered to represent movement disorders or dyskinesias. We have compared the ability of drugs to induce chewing and retching or emesis in squirrel monkeys; such studies are not possible in rodents, which do not vomit. Acute administration of oxotremorine (3.3-33 µg/kg IM), SKF38393 (1-30 mg/kg SC) or ipecacuanha (0.5-0.75 mg/kg PO) caused dose-related increases in purposeless chewing which was frequently associated with retching and emesis. Treatment with haloperidol (0.015-0.06 mg/kg IM) did not induce chewing. Rather, haloperidoldecreased spontaneous chewing at doses of 0.03 and 0.06 mg/kg. Our findings indicate that at least some drug-induced oral behaviours in rodents may reflect nausea rather than dyskinesia. Springer-Verlag, 1990 Dyskinesia nationallicence Nausea nationallicence Squirrel monkey nationallicence Emesis nationallicence Rupniak N. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, CM20 2QR, Harlow, Essex, UK aut Tye S. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, CM20 2QR, Harlow, Essex, UK aut Iversen S. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, CM20 2QR, Harlow, Essex, UK aut Psychopharmacology Springer-Verlag 102/3(1990-11-01), 325-328 0033-3158 102:3<325 1990 102 213 https://doi.org/10.1007/BF02244098 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244098 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rupniak N. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, CM20 2QR, Harlow, Essex, UK aut NATIONALLICENCE 700 1- Tye S. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, CM20 2QR, Harlow, Essex, UK aut NATIONALLICENCE 700 1- Iversen S. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, CM20 2QR, Harlow, Essex, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 325-328 0033-3158 102:3<325 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer