caa a22 4500 465737196 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244110 doi (NATIONALLICENCE)springer-10.1007/BF02244110 Antagonistic effect of physostigmine on ketamine-induced anesthesia [Elektronische Daten] [Mitsuko Mimura, Akiyoshi Namiki, Reiko Kishi, Toshiko Ikeda, Hirotsugu Miyake] Effects of physostigmine on ketamine-induced anesthesia and analgesia were studied in male Sprague-Dawley rats using behavioral tests. Rats were divided into six groups. Immediately after loss of the righting reflex following an intraperitoneal injection of ketamine 75 mg/kg, each group of rats was given an intraperitoneal injection of either physostigmine 0.05, 0.1, 0.2, 0.4, 0.6 mg/kg or saline as the control, respectively. Physostigmine 0.1 mg/kg caused the greatest antagonistic effect on ketamine anesthesia as indicated by sleeping time, duration of ataxia and motor coordination. The antagonistic effects of physostigmine were reduced by a dose of physostigmine of greater than 0.1 mg/kg. However, at no dose did physostigmine antagonize ketamine analgesia as indicated by the tail-flick latency. Physostigmine (0.4 and 0.6 mg/kg) itself had analgesic and motor-suppressive actions. It can therefore be presumed that there is a limited threshold of the dose of physostigmine which develops an antagonistic effect on ketamine anesthesia due to the motor-suppressive action. It is also confirmed that physostigmine itself produces analgesia, and does not antagonize ketamine-induced analgesia. Springer-Verlag, 1990 Antagonistic effect nationallicence Physostigmine nationallicence Ketamine nationallicence Anesthesia nationallicence Rat nationallicence Mimura Mitsuko Department of Anesthesiology, Sapporo Medical College, Minami-1, Nishi-16, Chuo-ku, 060, Sapporo, Japan aut Namiki Akiyoshi Department of Anesthesiology, Sapporo Medical College, Minami-1, Nishi-16, Chuo-ku, 060, Sapporo, Japan aut Kishi Reiko Department of Public Health, Sapporo Medical College, Sapporo, Japan aut Ikeda Toshiko Department of Public Health, Sapporo Medical College, Sapporo, Japan aut Miyake Hirotsugu Department of Public Health, Sapporo Medical College, Sapporo, Japan aut Psychopharmacology Springer-Verlag 102/3(1990-11-01), 399-403 0033-3158 102:3<399 1990 102 213 https://doi.org/10.1007/BF02244110 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244110 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mimura Mitsuko Department of Anesthesiology, Sapporo Medical College, Minami-1, Nishi-16, Chuo-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Namiki Akiyoshi Department of Anesthesiology, Sapporo Medical College, Minami-1, Nishi-16, Chuo-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Kishi Reiko Department of Public Health, Sapporo Medical College, Sapporo, Japan aut NATIONALLICENCE 700 1- Ikeda Toshiko Department of Public Health, Sapporo Medical College, Sapporo, Japan aut NATIONALLICENCE 700 1- Miyake Hirotsugu Department of Public Health, Sapporo Medical College, Sapporo, Japan aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 399-403 0033-3158 102:3<399 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer