caa a22 4500 46573720X CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244115 doi (NATIONALLICENCE)springer-10.1007/BF02244115 Rigdon Greg Pharmacology Division, Burroughs Wellcome Co., 27709, Research Triangle Park, NC, USA aut Differential effects of apomorphine on prepulse inhibition of acoustic startle reflex in two rat strains [Elektronische Daten] [Greg Rigdon] Apomorphine disruption of prepulse inhibition (PPI) has been proposed as an animal model of sensorimotor gating deficits exhibited by schizophrenics. The effects of apomorphine on PPI of the acoustic startle reflex in male rats of Wistar and CD (Sprague-Dawley derived) strains were compared under identical test conditions. In Wistar rats, subcutaneous administration of 0.25-1.0 mg/kg apomorphine blocked PPI without affecting startle amplitude. In CD rats, apomorphine (0.3-3.0 mg/kg, SC) had no effect on PPI, but increased startle amplitude. Therefore, choice of rat strain is an important factor in the design of experiments studying apomorphine effects on PPI. Springer-Verlag, 1990 Apomorphine nationallicence Startle reflex nationallicence Prepulse inhibition nationallicence Wistar strain nationallicence CD strain nationallicence Psychopharmacology Springer-Verlag 102/3(1990-11-01), 419-421 0033-3158 102:3<419 1990 102 213 https://doi.org/10.1007/BF02244115 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244115 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Rigdon Greg Pharmacology Division, Burroughs Wellcome Co., 27709, Research Triangle Park, NC, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 419-421 0033-3158 102:3<419 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer