caa a22 4500 465737226 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244100 doi (NATIONALLICENCE)springer-10.1007/BF02244100 Effects of chlordiazepoxide and flumazenil on preference for punished and unpunished response alternatives in rats [Elektronische Daten] [D. Thomas, S. Weiss, C. Schindler] Male food-restricted hooded rats were trained to respond on a two-component multiple schedule. Reinforcement density was several times higher in one component than in the other. However, responses were intermittently punished with shock in the richer reinforcement component (conflict situation). Shock intensities were adjusted to produce mild and strong suppression of responding in two separate phases. Half of the rats controlled which component was operating (Preference group) and half did not (Yoked group). The effect of chlordiazepoxide (CDZ; 0, 1, 3, and 10 mg/kg; IP) was measured on component preference and response rate. Chlordiazepoxide increased both time spent in the conflict situation and response rate in that component. This is the first study employing a schedule that permitted these two behavioral indices to be measured independently in a conflict paradigm. Response rates were also increased in the unpunished response alternative, but to a lesser degree than in the conflict situation. The effects of CDZ were at least partially mediated by the benzodiazepine receptor because CDZ's effects were diminished by flumanezil (10 mg/kg; IP), a benzodiazepine antagonist. Springer-Verlag, 1990 Chlordiazepoxide nationallicence Flumazenil nationallicence Preference nationallicence Multiple schedule nationallicence Conflict nationallicence Rats nationallicence Thomas D. Department of Psychology, The American University, 321 Asbury Building, 20016, Washington, DC, USA aut Weiss S. Department of Psychology, The American University, 321 Asbury Building, 20016, Washington, DC, USA aut Schindler C. Behavioral Pharmacology and Genetics Laboratory, Preclinical Pharmacology Branch, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 102/3(1990-11-01), 333-338 0033-3158 102:3<333 1990 102 213 https://doi.org/10.1007/BF02244100 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244100 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thomas D. Department of Psychology, The American University, 321 Asbury Building, 20016, Washington, DC, USA aut NATIONALLICENCE 700 1- Weiss S. Department of Psychology, The American University, 321 Asbury Building, 20016, Washington, DC, USA aut NATIONALLICENCE 700 1- Schindler C. Behavioral Pharmacology and Genetics Laboratory, Preclinical Pharmacology Branch, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 333-338 0033-3158 102:3<333 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer