caa a22 4500 465737234 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244104 doi (NATIONALLICENCE)springer-10.1007/BF02244104 Effects of GABAA receptor ligands on noradrenaline concentration and β-adrenoceptor binding in mouse cerebral cortex [Elektronische Daten] [D. Gettins, N. Goldsack, V. Ibegbuna, S. Stanford] The present experiments investigated changes in β-adrenoceptor binding and noradrenaline stores in mouse cerebral cortex after single treatments with drugs which bind to the GABAA receptor but which attenuate the actions of GABA. Neither the GABA antagonist, securinine, nor the picrotoxin/Cl− channel ligand, picrotoxin, affected noradrenaline levels or β-adrenoceptor binding. However, both the benzodiazepine inverse agonist, DMCM, and pentylenetetrazole increased noradrenaline levels 24 h after injection. Only pentylenetetrazol modified β-adrenoceptor binding: there was a significant increase in receptor number 4 days after injection, but a significant decrease after 7 days. The anxiogenic, proconvulsant drug, yohimbine, was without effect. The changes induced by DMCM and pentylenetetrazole do not seem to be related to the behavioural effects of these drugs or to their affinity for binding to benzodiazepine receptors. The possibility that these compounds have actions in addition to those at the GABAA receptor is discussed. Springer-Verlag, 1990 β-adrenoceptor nationallicence GABAA receptor nationallicence Noradrenaline nationallicence Mouse nationallicence Gettins D. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK aut Goldsack N. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK aut Ibegbuna V. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK aut Stanford S. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK aut Psychopharmacology Springer-Verlag 102/3(1990-11-01), 357-363 0033-3158 102:3<357 1990 102 213 https://doi.org/10.1007/BF02244104 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244104 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gettins D. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Goldsack N. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Ibegbuna V. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Stanford S. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 357-363 0033-3158 102:3<357 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer