caa a22 4500 465737242 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244108 doi (NATIONALLICENCE)springer-10.1007/BF02244108 Genetic differences in maternal behaviour patterns in mice administered phenobarbital during pregnancy [Elektronische Daten] [Giovanni Laviola, Kofi Sedowofia, Joanne Innes, Ruth Clayton, Aubrey Manning] In a study designed to examine the role of the genotype on sensitivity to drug-induced behavioural changes, pregnant C57BL/6J and CBA mice were administered 60 mg/kg phenobarbital (PHB) intraperitoneally during days 10-16 of gestation. Following a balanced intrastrain fostering procedure, the behaviour of lactating dams was observed in their home cage at 2, 3, 5, 7 and 14 days postpartum. As the pups became older, maternal behaviour declined in control groups, whereas PHB dams of the CBA strain persisted in nursing their pups. C57 dams were generally affected in an opposite way by PHB exposure. For example, treated dams spent significantly less time in licking behaviour. Nest quality score was especially elevated in PHB dams of the CBA strain, while in C57 dams, nest-building was inhibited and nest quality unaffected by the previous PHB exposure. These results indicate that specific items of maternal behaviour can be differently affected by PHB exposure, and that the responses are affected by the genotype. To summarise, pups raised by treated dams may receive either exaggerated or insufficient maternal attention, as a result of changes in neurotransmitter systems and behavioural regulation following phenobarbital exposure. These results point to the need for a better understanding of mother/pup interactions in studies aimed at characterizing drug and toxicant effects on postnatal development. Springer-Verlag, 1990 Phenobarbital nationallicence Gestational barbiturate exposure nationallicence Maternal behaviour nationallicence Mouse genotype nationallicence Laviola Giovanni Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita', Viale Regina Elena 299, I-00161, Roma, Italy aut Sedowofia Kofi Department of Genetics, University of Edinburgh, West Mains Road, EH9 3JN, Edinburgh, UK aut Innes Joanne Department of Zoology, University of Edinburgh, West Mains Road, EH9 3JN, Edinburgh, UK aut Clayton Ruth Department of Genetics, University of Edinburgh, West Mains Road, EH9 3JN, Edinburgh, UK aut Manning Aubrey Department of Zoology, University of Edinburgh, West Mains Road, EH9 3JN, Edinburgh, UK aut Psychopharmacology Springer-Verlag 102/3(1990-11-01), 383-390 0033-3158 102:3<383 1990 102 213 https://doi.org/10.1007/BF02244108 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244108 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Laviola Giovanni Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita', Viale Regina Elena 299, I-00161, Roma, Italy aut NATIONALLICENCE 700 1- Sedowofia Kofi Department of Genetics, University of Edinburgh, West Mains Road, EH9 3JN, Edinburgh, UK aut NATIONALLICENCE 700 1- Innes Joanne Department of Zoology, University of Edinburgh, West Mains Road, EH9 3JN, Edinburgh, UK aut NATIONALLICENCE 700 1- Clayton Ruth Department of Genetics, University of Edinburgh, West Mains Road, EH9 3JN, Edinburgh, UK aut NATIONALLICENCE 700 1- Manning Aubrey Department of Zoology, University of Edinburgh, West Mains Road, EH9 3JN, Edinburgh, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 383-390 0033-3158 102:3<383 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer