caa a22 4500 465737250 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02244097 doi (NATIONALLICENCE)springer-10.1007/BF02244097 Environment-dependent effects of ethanol on DOPAC and HVA in various brain regions of ethanol-tolerant rats [Elektronische Daten] [Sture Liljequist, Agneta Ekman, Barry Snape, Bo Söderpalm, Jörgen Engel] The development of tolerance to the behavioral and biochemical effects of ethanol was studied. Rats were made tolerant to ethanol by the administration of daily ethanol injections (3 g/kg, IP) for 7 and 28 days. Tolerance developed both to the behavioral (hypothermic, sedative) and biochemical (accumulation of dopamine metabolites in various brain areas) actions of ethanol. However, it was found that this tolerance to both the behavioral and biochemical effects of ethanol was no longer present when previously ethanol-tolerant animals were moved from their home environment and given a challenge dose of ethanol (2.5 g/kg; IP) in a new, unfamiliar environment. Our findings confirm that ethanol tolerance cannot be explained on the basis of a singular neurochemical event. The development of ethanol tolerance is due to a complex interaction between environmental, learning, and biochemical factors. Springer-Verlag, 1990 Ethanol nationallicence Tolerance nationallicence Hypothermia nationallicence DOPAC nationallicence HVA nationallicence Rat brain nationallicence Liljequist Sture Department of Pharmacology, P.O. Box 33031, S-40033, Göteborg, Sweden aut Ekman Agneta Department of Pharmacology, P.O. Box 33031, S-40033, Göteborg, Sweden aut Snape Barry Department of Pharmacology, P.O. Box 33031, S-40033, Göteborg, Sweden aut Söderpalm Bo Department of Pharmacology, P.O. Box 33031, S-40033, Göteborg, Sweden aut Engel Jörgen Department of Pharmacology, P.O. Box 33031, S-40033, Göteborg, Sweden aut Psychopharmacology Springer-Verlag 102/3(1990-11-01), 319-324 0033-3158 102:3<319 1990 102 213 https://doi.org/10.1007/BF02244097 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244097 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liljequist Sture Department of Pharmacology, P.O. Box 33031, S-40033, Göteborg, Sweden aut NATIONALLICENCE 700 1- Ekman Agneta Department of Pharmacology, P.O. Box 33031, S-40033, Göteborg, Sweden aut NATIONALLICENCE 700 1- Snape Barry Department of Pharmacology, P.O. Box 33031, S-40033, Göteborg, Sweden aut NATIONALLICENCE 700 1- Söderpalm Bo Department of Pharmacology, P.O. Box 33031, S-40033, Göteborg, Sweden aut NATIONALLICENCE 700 1- Engel Jörgen Department of Pharmacology, P.O. Box 33031, S-40033, Göteborg, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/3(1990-11-01), 319-324 0033-3158 102:3<319 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer