caa a22 4500 465737285 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02247140 doi (NATIONALLICENCE)springer-10.1007/BF02247140 Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning [Elektronische Daten] [Christian Chiamulera, Silvano Costa, Angelo Reggiani] Intracerebroventricular (ICV) injection of N-methyl-d-aspartate (NMDA) was shown to induce generalized seizures in mice. The competitive NMDA antagonistsdl-2-amino-5-phosphonovaleroate (dl-AP7) and 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP), the NMDA "channel blocker” antagonist (+)-5-methyl-10,11-dihydro 5H-dibenzo-[a,d] cycloheptan-5,10-imine maleate (MK-801) and the strychnine-insensitive glycine antagonists kynurenic acid (KYNA) and 7-chloro-kynurenic acid (7-Cl-KYNA), when co-administered (ICV) with NMDA, antagonized NMDA-induced generalized seizures. Administration (ICV) ofdl-AP7, CPP and MK-801 resulted in impared learning performance in a passive avoidance task in mice, with ED50 close to the anticonvulsant dose. The glycine antagonists KYNA and 7-Cl-KYNA at high doses significantly failed to affect performance in the same model of learning. The results indicate that compounds acting at the strychnine-insensitive glycine site may have a larger "therapeutic window” as anticonvulsants than antagonists of the NMDA receptor and channel. Springer-Verlag, 1990 NMDA receptor antagonists nationallicence Glycine antagonists nationallicence Convulsions nationallicence Learning nationallicence Chiamulera Christian Glaxo Research Laboratories, Via Fleming 2, I-37135, Verona, Italy aut Costa Silvano Glaxo Research Laboratories, Via Fleming 2, I-37135, Verona, Italy aut Reggiani Angelo Glaxo Research Laboratories, Via Fleming 2, I-37135, Verona, Italy aut Psychopharmacology Springer-Verlag 102/4(1990-12-01), 551-552 0033-3158 102:4<551 1990 102 213 https://doi.org/10.1007/BF02247140 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247140 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chiamulera Christian Glaxo Research Laboratories, Via Fleming 2, I-37135, Verona, Italy aut NATIONALLICENCE 700 1- Costa Silvano Glaxo Research Laboratories, Via Fleming 2, I-37135, Verona, Italy aut NATIONALLICENCE 700 1- Reggiani Angelo Glaxo Research Laboratories, Via Fleming 2, I-37135, Verona, Italy aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/4(1990-12-01), 551-552 0033-3158 102:4<551 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer