caa a22 4500 46573734X CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02247134 doi (NATIONALLICENCE)springer-10.1007/BF02247134 Reduced haloperidol plasma concentration and clinical response in acute exacerbations of schizophrenia [Elektronische Daten] [Michael Kelly, Paul Perry, William Coryell, D. Del Miller, Stephan Arndt] Twenty-nine hospitalized patients suffering acute exacerbations of schizophrenia were treated for 2 weeks with fixed daily oral doses of haloperidol prospectively calculated to achieve a haloperidol plasma concentration of either 8-18 ng/ml or 25-35 ng/ml. Reduced haloperidol as well as haloperidol concentrations were assayed to determine if the former enhanced the predictability of response. Week 2 haloperidol plasma concentrations were negatively correlated to clinical response as measured by the percentage change in the BPRS score from baseline (r=−0.43,P<0.05). In contrast, week 2 plasma concentrations of reduced haloperidol, total haloperidol (haloperidol+reduced haloperidol), and reduced haloperidol/haloperidol ratio did not correlate with the change in the BPRS score. Chi-square analysis concluded that patients with ratios greater than one were no less likely to be treatment responders (<25% improvement in BPRS from baseline and week 2 BPRS <55) than those with ratios less than one. Although these data lend additional support to reports of a curvilinear relationship between haloperidol plasma concentration and clinical response, they also suggest that reduced haloperidol plasma concentrations are of no value in predicting treatment response. Springer-Verlag, 1990 Haloperidol nationallicence Reduced haloperidol nationallicence Schizophrenia nationallicence Kelly Michael Division of Clinical Pharmacy, College of Pharmacy, University of Iowa, 52242, Iowa City, IA, USA aut Perry Paul Department of Psychiatry, College of Medicine, 52242, Iowa City, IA, USA aut Coryell William Department of Psychiatry, College of Medicine, 52242, Iowa City, IA, USA aut Del Miller D. Department of Psychiatry, College of Medicine, 52242, Iowa City, IA, USA aut Arndt Stephan Department of Psychiatry, College of Medicine, 52242, Iowa City, IA, USA aut Psychopharmacology Springer-Verlag 102/4(1990-12-01), 514-520 0033-3158 102:4<514 1990 102 213 https://doi.org/10.1007/BF02247134 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247134 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kelly Michael Division of Clinical Pharmacy, College of Pharmacy, University of Iowa, 52242, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Perry Paul Department of Psychiatry, College of Medicine, 52242, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Coryell William Department of Psychiatry, College of Medicine, 52242, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Del Miller D. Department of Psychiatry, College of Medicine, 52242, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Arndt Stephan Department of Psychiatry, College of Medicine, 52242, Iowa City, IA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/4(1990-12-01), 514-520 0033-3158 102:4<514 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer