caa a22 4500 465737358 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02247142 doi (NATIONALLICENCE)springer-10.1007/BF02247142 Discrimination of an amphetamine-pentobarbitone mixture by rats in an AND-OR paradigm [Elektronische Daten] [I. Stolerman, E. Mariathasan] Rats were trained to discriminate a mixture of amphetamine plus pentobarbitone from either drug separately in a two-bar procedure with food reinforcement. Discrimination was 86% accurate after 48 sessions, and no dose of amphetamine or pentobarbitone alone produced mixture-appropriate responding. Some mixtures increased response rates whereas the same doses of each drug separately had little effect. The same rats were then trained to discriminate a mixture from saline. There was a continuing lack of discriminative response to amphetamine and only a partial response to pentobarbitone, and under these conditions mixtures did not increase overall response rates. Thus, the way rats are trained, and their previous history, can determine the characteristics of the cue obtained. Springer-Verlag, 1990 Amphetamine nationallicence Pentobarbitone nationallicence Drug discrimination nationallicence Rats nationallicence Stolerman I. Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK aut Mariathasan E. Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK aut Psychopharmacology Springer-Verlag 102/4(1990-12-01), 557-560 0033-3158 102:4<557 1990 102 213 https://doi.org/10.1007/BF02247142 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247142 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stolerman I. Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Mariathasan E. Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/4(1990-12-01), 557-560 0033-3158 102:4<557 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer