caa a22 4500 465737366 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02247127 doi (NATIONALLICENCE)springer-10.1007/BF02247127 Neuroleptic-induced vacuous chewing movements as an animal model of tardive dyskinesia: a study in three rat strains [Elektronische Daten] [C. Tamminga, J. Dale, L. Goodman, H. Kaneda, N. Kaneda] Vacuous chewing movements (VCMs) in three different rat strains developed at considerably different rates after 19 weeks of continual haloperidol treatment at an average daily dose of 1.5 mg/kg. Sprague Dawley (SD) rats displayed relatively high rates of VCMs with low variability, compared to Wistar (W) and Long Evan (LE) rats. Atropine decreased but did not abolish VCMs in two of the three strains (LE>SD). After haloperidol withdrawal, VCMs remitted gradually in all strains, but least rapidly in the SD rats. In a separate group of SD rats, VCMs were rated weekly from the start of haloperidol treatment and showed considerable interindividual variability. Even after 24 weeks of continuous haloperidol, 12 out of 32 treated rats showed no VCMs at all, while 13 out of 32 had intense movements, analogous to the clinical situation in which only some patients treated with neuroleptics develop tardive dyskinesia. These results indicate that there are individual and strain differences in the development of VCMs, and suggest that there may also be genetically determined differences in the development of tardive dyskinesia. Springer-Verlag, 1990 Animal model nationallicence Tardive dyskinesia nationallicence Chronic haloperidol nationallicence Rat strains nationallicence Neuroleptic nationallicence Tamminga C. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, 21228, Baltimore, MD, USA aut Dale J. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, 21228, Baltimore, MD, USA aut Goodman L. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, 21228, Baltimore, MD, USA aut Kaneda H. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, 21228, Baltimore, MD, USA aut Kaneda N. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, 21228, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 102/4(1990-12-01), 474-478 0033-3158 102:4<474 1990 102 213 https://doi.org/10.1007/BF02247127 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247127 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tamminga C. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, 21228, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Dale J. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, 21228, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Goodman L. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, 21228, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Kaneda H. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, 21228, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Kaneda N. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, 21228, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/4(1990-12-01), 474-478 0033-3158 102:4<474 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer