caa a22 4500 465737390 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02247128 doi (NATIONALLICENCE)springer-10.1007/BF02247128 Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits [Elektronische Daten] [Marino Massotti, Dario De Medici, Carlo De Luca] The effects of benzodiazepine receptor agonists on the electrical activity of red nucleus (RN) and neocortex were studied in rabbits. Under basal conditions, 30-40 µV, 40-50 Hz waves were recorded in RN. An increase of the amplitude (Emax, 75-90 µV) was found after IV injection of flunitrazepam (ED50, 0.14 mg/kg), diazepam (ED50, 0.28 mg/kg), alpidem (ED50, 1.57 mg/kg) and zolpidem (ED50, 0.73 mg/kg). Clonazepam (ED50, 0.12 mg/kg) and C1 218,872 (ED50, 0.63 mg/kg) were less effective. In contrast, 2-10-fold higher doses were required to induce a slight decrease of the frequency. At the level of the cortex all benzodiazepine agonists induced synchronization and spindles. The effects of diazepam (5 mg/kg IV) in both areas were antagonized by flumazenil (0.04 mg/kg IV) and bicuculline (0.2 mg/kg IV). Pentamethylentetrazole (10-30 mg/kg IV) selectively abated the effect at the level of the cortex, whereas both clonazepam (2 mg/kg IV) and β-CCM (0.6 mg/kg IV) selectively suppressed only the effects on the RN. These results suggest that activation of benzodiazepine receptor mainly influences the RN waves amplitude. The efficacy in increasing the amplitude appears related to the reported relative efficacy of the compound in potentiating GABA responses. The possibility exists that these effects are dependent upon the partial or full agonist action of the drugs or upon their binding at distinct benzodiazepine receptor types. Springer-Verlag, 1990 Benzodiazepines nationallicence Imidazopyridines nationallicence Triazolopyridazines nationallicence Red nucleus nationallicence Rabbit nationallicence Massotti Marino Laboratorio di Farmacologia, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161, Roma, Italy aut De Medici Dario Laboratorio di Farmacologia, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161, Roma, Italy aut De Luca Carlo Laboratorio di Farmacologia, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161, Roma, Italy aut Psychopharmacology Springer-Verlag 102/4(1990-12-01), 479-484 0033-3158 102:4<479 1990 102 213 https://doi.org/10.1007/BF02247128 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247128 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Massotti Marino Laboratorio di Farmacologia, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161, Roma, Italy aut NATIONALLICENCE 700 1- De Medici Dario Laboratorio di Farmacologia, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161, Roma, Italy aut NATIONALLICENCE 700 1- De Luca Carlo Laboratorio di Farmacologia, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161, Roma, Italy aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/4(1990-12-01), 479-484 0033-3158 102:4<479 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer