caa a22 4500 465737404 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02247122 doi (NATIONALLICENCE)springer-10.1007/BF02247122 Drug interactions in the reinforcing effects of over-the-counter cough syrups [Elektronische Daten] [Tsutomu Suzuki, Yoshikazu Masukawa, Miwa Misawa] Drug interactions in reinforcing effects of over-the-counter cough syrups were investigated by utilizing place preference conditioning in rats. Dihydrocodeine (2 mg/kg, IP) induced a small, non-significant place preference. On the other hand, concurrent dosing of dihydrocodeine (2 mg/kg, IP) and a mixture (SC) of methylephedrine (4 mg/kg), caffeine (4 mg/kg) and chlorpheniramine (0.8 mg/kg) produced a significant place preference, the mean conditioning score in this group being about 3 times higher than that in the dihydrocodeine alone group. The potentiation of dihydrocodeine-conditioned place preference was observed by combination with chlorpheniramine (0.8 mg/kg, SC) alone as well as with the mixture, but neither with methylephedrine (4 mg/kg, SC) nor with caffeine (4 mg/kg, SC). Chronic infusion of the dopamine D1 receptor antagonist SCH23390 (1.0 mg/kg/day, SC) during conditioning abolished the appetitive effects of dihydrocodeine combined with chlorpheniramine. In conclusion, it is suggested that the potentiation of appetitive effects of dihydrocodeine is mostly due to chlorpheniramine among three ingredients in the cough syrups, and that the dopaminergic system, especially D1 receptor, may play an important role in the potentiation effect of chlorpheniramine on the reinforcing effects of dihydrocodeine. Springer-Verlag, 1990 Dihydrocodeine nationallicence Chlorpheniramine nationallicence SCH23390 nationallicence Place preference nationallicence Dopamine D1 receptor nationallicence Suzuki Tsutomu Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, 142, Tokyo, Japan aut Masukawa Yoshikazu Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, 142, Tokyo, Japan aut Misawa Miwa Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, 142, Tokyo, Japan aut Psychopharmacology Springer-Verlag 102/4(1990-12-01), 438-442 0033-3158 102:4<438 1990 102 213 https://doi.org/10.1007/BF02247122 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247122 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suzuki Tsutomu Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, 142, Tokyo, Japan aut NATIONALLICENCE 700 1- Masukawa Yoshikazu Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, 142, Tokyo, Japan aut NATIONALLICENCE 700 1- Misawa Miwa Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, 142, Tokyo, Japan aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/4(1990-12-01), 438-442 0033-3158 102:4<438 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer