caa a22 4500 465737412 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02247124 doi (NATIONALLICENCE)springer-10.1007/BF02247124 Effects of intranasal cocaine on human learning, performance and physiology [Elektronische Daten] [Stephen Higgins, Warren Bickel, John Hughes, Mary Lynn, Mark Capeless, James Fenwick] The behavioral and physiological effects of intranasally administered cocaine (placebo, 48, 96 mg/70 kg) were examined in eight recreational cocaine users under controlled laboratory conditions. The 48 and 96 mg doses of cocaine significantly improved subjects' performance on the Digit Symbol Substitution Test above levels observed either prior to drug administration or when placebo was administered. These effects were discernible for up to 120 min after cocaine administration. Cocaine had no statistically significant effects on learning and performance of ten-response sequences. The 48 and 96 mg doses increased heart rate and blood pressure for up to 180 min, and increased subject ratings of drug effects and decreased skin temperature for 60-90 min after drug administration. Cocaine produced no significant effects on the electrocardiogram. To our knowledge, this is the first experimental demonstration that acutely administered cocaine can improve behavioral performance in rested subjects. In addition, the duration of cardiac effects in this study was longer than previously reported with intranasal cocaine, perhaps due to the concurrent behavioral testing. Springer-Verlag, 1990 Cocaine nationallicence Psychomotor performance nationallicence Learning nationallicence Heart rate nationallicence Humans nationallicence Higgins Stephen Departments of Psychiatry, Psychology, Medicine, and Biostatistics, University of Vermont, Burlington, Vermont, USA aut Bickel Warren Departments of Psychiatry, Psychology, Medicine, and Biostatistics, University of Vermont, Burlington, Vermont, USA aut Hughes John Departments of Psychiatry, Psychology, Medicine, and Biostatistics, University of Vermont, Burlington, Vermont, USA aut Lynn Mary Departments of Psychiatry, Psychology, Medicine, and Biostatistics, University of Vermont, Burlington, Vermont, USA aut Capeless Mark Departments of Psychiatry, Psychology, Medicine, and Biostatistics, University of Vermont, Burlington, Vermont, USA aut Fenwick James Departments of Psychiatry, Psychology, Medicine, and Biostatistics, University of Vermont, Burlington, Vermont, USA aut Psychopharmacology Springer-Verlag 102/4(1990-12-01), 451-458 0033-3158 102:4<451 1990 102 213 https://doi.org/10.1007/BF02247124 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247124 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Higgins Stephen Departments of Psychiatry, Psychology, Medicine, and Biostatistics, University of Vermont, Burlington, Vermont, USA aut NATIONALLICENCE 700 1- Bickel Warren Departments of Psychiatry, Psychology, Medicine, and Biostatistics, University of Vermont, Burlington, Vermont, USA aut NATIONALLICENCE 700 1- Hughes John Departments of Psychiatry, Psychology, Medicine, and Biostatistics, University of Vermont, Burlington, Vermont, USA aut NATIONALLICENCE 700 1- Lynn Mary Departments of Psychiatry, Psychology, Medicine, and Biostatistics, University of Vermont, Burlington, Vermont, USA aut NATIONALLICENCE 700 1- Capeless Mark Departments of Psychiatry, Psychology, Medicine, and Biostatistics, University of Vermont, Burlington, Vermont, USA aut NATIONALLICENCE 700 1- Fenwick James Departments of Psychiatry, Psychology, Medicine, and Biostatistics, University of Vermont, Burlington, Vermont, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/4(1990-12-01), 451-458 0033-3158 102:4<451 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer