caa a22 4500 465737447 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02247136 doi (NATIONALLICENCE)springer-10.1007/BF02247136 Lateral striatal cholinergic mechanisms involved in oral motor activities in the rat [Elektronische Daten] [J. Salamone, C. Johnson, L. McCullough, R. Steinpreis] These experiments were undertaken to determine if local injection of pilocarpine in the neostriatum of the rat produces oral motor activities that are similar to those produced by systemic administration. In the first experiment, IP administration of 2.0-8.0 mg/kg pilocarpine increased chewing movements and tongue protrusions. In the second experiment, chronic guide cannulae were implanted bilaterally in ventromedial or ventrolateral striatum, and rats were injected with saline, 30, and 60 µg pilocarpine (per side). A dose-related increase in vaculous chewing was induced by injections of pilocarpine in the ventrolateral but not the ventromedial striatum. Tongue protrusions were induced by injections of pilocarpine into the ventromedial and the ventrolateral striatum. A third experiment demonstrated that this response was blocked completely by 10 µg scopolamine co-administered via the same cannulae, but the response was not reduced significantly by 10 µg haloperidol. These results indicate that ventrolateral striatal cholinergic mechanisms are involved in oral motor activities in the rat. This syndrome may provide a model for human clinical phenomena such as parkinsonian tremor. Springer-Verlag, 1990 Pilocarpine nationallicence Muscarinic receptors nationallicence Chewing nationallicence Movement nationallicence Parkinonism nationallicence Salamone J. Department of Psychology, University of Connecticut, 06269-1020, Storrs, CT, USA aut Johnson C. Department of Psychology, University of Connecticut, 06269-1020, Storrs, CT, USA aut McCullough L. Department of Psychology, University of Connecticut, 06269-1020, Storrs, CT, USA aut Steinpreis R. Department of Psychology, University of Connecticut, 06269-1020, Storrs, CT, USA aut Psychopharmacology Springer-Verlag 102/4(1990-12-01), 529-534 0033-3158 102:4<529 1990 102 213 https://doi.org/10.1007/BF02247136 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247136 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Salamone J. Department of Psychology, University of Connecticut, 06269-1020, Storrs, CT, USA aut NATIONALLICENCE 700 1- Johnson C. Department of Psychology, University of Connecticut, 06269-1020, Storrs, CT, USA aut NATIONALLICENCE 700 1- McCullough L. Department of Psychology, University of Connecticut, 06269-1020, Storrs, CT, USA aut NATIONALLICENCE 700 1- Steinpreis R. Department of Psychology, University of Connecticut, 06269-1020, Storrs, CT, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/4(1990-12-01), 529-534 0033-3158 102:4<529 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer