caa a22 4500 465737471 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02247123 doi (NATIONALLICENCE)springer-10.1007/BF02247123 Cocaine-base smoking in rhesus monkeys: reinforcing and physiological effects [Elektronische Daten] [Marilyn Carroll, Kelly Krattiger, Daniel Gieske, Daniel Sadoff] Four rhesus monkeys were trained to smoke cocaine-base under a progressive ratio (PR) schedule, with ten smoking trials available each day. Unit dose was varied from 0.25 to 3 mg/kg, and lidocaine (2 mg/kg) was substituted for cocaine. Number of responses and break-point on the PR schedule increased with dose while the number of smoke deliveries increased only slightly. Maximum daily smoke deliveries ranged from six to nine across monkeys. When lidocaine (2 mg/kg) was substituted for cocaine-base, responding decreased to approximately half of that maintained by cocaine, and when cocaine was reinstated, higher response rates returned. Cardiovascular changes associated with cocaine smoking were monitored with an indwelling radio transmitter. There was an initial decrease in heart rate (30 s) followed by a rapid rise and decline by the end of the 15-min trials. Blood pressure increased rapidly after trial onset and returned to pretrial baseline by 15 min. Over the eight trials completed during a session, heart rate and blood pressure steadily increased over presession baselines during the first four trials, but there was then a decline suggesting acute tolerance development. Observations of the monkeys after each trial revealed dilated pupils and slightly agitated, hyperactive behavior. These findings indicated that smoked cocaine-base was rapidly established as a reinforcer for monkeys, and the physiological effects were similar to those reported in studies of human subjects. Springer-Verlag, 1990 Cardiovascular effects nationallicence Cocaine-base nationallicence Monkeys nationallicence Self-administration nationallicence Smoking nationallicence Carroll Marilyn Department of Psychiatry, Medicine University of Minnesota, Medical School, Box 392 Mayo, 55455, Minneapolis, MN, USA aut Krattiger Kelly Department of Psychiatry, Medicine University of Minnesota, Medical School, Box 392 Mayo, 55455, Minneapolis, MN, USA aut Gieske Daniel Department of Psychiatry, Medicine University of Minnesota, Medical School, Box 392 Mayo, 55455, Minneapolis, MN, USA aut Sadoff Daniel Division of Comparative, Medicine University of Minnesota, Medical School, Box 392 Mayo, 55455, Minneapolis, MN, USA aut Psychopharmacology Springer-Verlag 102/4(1990-12-01), 443-450 0033-3158 102:4<443 1990 102 213 https://doi.org/10.1007/BF02247123 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247123 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carroll Marilyn Department of Psychiatry, Medicine University of Minnesota, Medical School, Box 392 Mayo, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Krattiger Kelly Department of Psychiatry, Medicine University of Minnesota, Medical School, Box 392 Mayo, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Gieske Daniel Department of Psychiatry, Medicine University of Minnesota, Medical School, Box 392 Mayo, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Sadoff Daniel Division of Comparative, Medicine University of Minnesota, Medical School, Box 392 Mayo, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/4(1990-12-01), 443-450 0033-3158 102:4<443 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer